Host inhibits replication of European porcine reproductive and respiratory syndrome virus in macrophages by altering differential regulation of type-I interferon transcriptional response

T. Ait-Ali, Alison Wilson, W. Carre, D. Westcott, J.-P. Frossard, M. Mellencamp, D. Mouzaki, O. Matika, D. Waddington, T. Drew, S. Bishop, A. Archibald

Research output: Contribution to journalArticlepeer-review

Abstract

Porcine reproductive and respiratory syndrome (PRRS) is an infectious disease caused by a positive RNA strand arterivirus. PRRS virus (PRRSV) interacts primarily with lung macrophages. Little is known how the virus subverts the innate immune response to initiate its replication in alveolar macrophages. Large-scale transcriptional responses of macrophages with different levels of susceptibility to PRRSV infection were compared over 30 h of infection. This study demonstrates a rapid and intense host transcriptional remodelling during the early phase of the replication of the virus which correlates with transient repression of type-I interferon transcript as early as 8 h post-infection. These results support the suggestion from previous studies that host innate immune response inhibits replication of European porcine reproductive and respiratory syndrome virus in macrophages by altering differential regulation of type-I interferon transcriptional response.

Original languageEnglish
Pages (from-to)437-448
Number of pages12
JournalImmunogenetics
Volume63
Issue number7
DOIs
Publication statusPublished - Jul 2011

Keywords

  • Swine
  • POPULATIONS
  • GENE-EXPRESSION
  • SUSCEPTIBILITY
  • PRRSV
  • Alveolar macrophage
  • DENDRITIC CELLS
  • PIGS
  • Innate immunity
  • ARTERIVIRUS
  • ACTIVATION
  • Interferon response
  • INFECTION
  • MICROARRAY EXPERIMENTS
  • SWINE ALVEOLAR MACROPHAGES

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