Abstract / Description of output
Mycobacterium leprae has the capacity to invade the peripheral nervous system and cause neuropathy. The molecular mechanisms responsible have remained unknown until recently. Identification of the endoneurial laminin-2 isoform and its receptor alpha-dystroglycan as neural targets of M. leprae has not only opened up a new area of scientific inquiry into the pathogenesis of neurological damage in leprosy, but has also revealed unexpected biological properties of these important host molecules.
| Original language | English |
|---|---|
| Pages (from-to) | 23-8 |
| Number of pages | 6 |
| Journal | Trends in Microbiology |
| Volume | 8 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 1 Jan 2000 |
Keywords / Materials (for Non-textual outputs)
- Cytoskeletal Proteins/metabolism
- Dystroglycans
- Humans
- Laminin/chemistry
- Leprosy/microbiology
- Membrane Glycoproteins/metabolism
- Mycobacterium leprae/pathogenicity
- Myelin Sheath/metabolism
- Peripheral Nerves/chemistry
- Peripheral Nervous System Diseases/microbiology
- Protein Isoforms/chemistry
- Protein Structure, Tertiary
- Schwann Cells/microbiology