How does Mycobacterium leprae target the peripheral nervous system?

Research output: Contribution to journalReview articlepeer-review

Abstract / Description of output

Mycobacterium leprae has the capacity to invade the peripheral nervous system and cause neuropathy. The molecular mechanisms responsible have remained unknown until recently. Identification of the endoneurial laminin-2 isoform and its receptor alpha-dystroglycan as neural targets of M. leprae has not only opened up a new area of scientific inquiry into the pathogenesis of neurological damage in leprosy, but has also revealed unexpected biological properties of these important host molecules.

Original languageEnglish
Pages (from-to)23-8
Number of pages6
JournalTrends in Microbiology
Issue number1
Publication statusPublished - 1 Jan 2000

Keywords / Materials (for Non-textual outputs)

  • Cytoskeletal Proteins/metabolism
  • Dystroglycans
  • Humans
  • Laminin/chemistry
  • Leprosy/microbiology
  • Membrane Glycoproteins/metabolism
  • Mycobacterium leprae/pathogenicity
  • Myelin Sheath/metabolism
  • Peripheral Nerves/chemistry
  • Peripheral Nervous System Diseases/microbiology
  • Protein Isoforms/chemistry
  • Protein Structure, Tertiary
  • Schwann Cells/microbiology


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