How Genomics Is Changing What We Know About the Evolution and Genome of Bordetella pertussis

Natalie Ring, Jonathan S. Abrahams, Stefan Bagby, Andrew Preston, Iain MacArthur*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract / Description of output

The evolution of Bordetella pertussis from a common ancestor similar to Bordetella bronchiseptica has occurred through large-scale gene loss, inactivation and rearrangements, largely driven by the spread of insertion sequence element repeats throughout the genome. B. pertussis is widely considered to be monomorphic, and recent evolution of the B. pertussis genome appears to, at least in part, be driven by vaccine-based selection. Given the recent global resurgence of whooping cough despite the wide-spread use of vaccination, a more thorough understanding of B. pertussis genomics could be highly informative. In this chapter we discuss the evolution of B. pertussis, including how vaccination is changing the circulating B. pertussis population at the gene-level, and how new sequencing technologies are revealing previously unknown levels of inter- and intra-strain variation at the genome-level.

Original languageEnglish
Title of host publicationAdvances in Experimental Medicine and Biology
Number of pages17
Publication statusPublished - 19 Jul 2019

Publication series

NameAdvances in Experimental Medicine and Biology
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Keywords / Materials (for Non-textual outputs)

  • Bordetella pertussis
  • DNA sequencing
  • Evolution
  • Genomic variation
  • Whooping cough


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