How to build the fastest receptor on earth

Jelena Baranovic, Andrew J R Plested

Research output: Contribution to journalReview articlepeer-review

Abstract

In 2014, a slew of structures of glutamate receptors were published, based on crystallography and electron microscopy. Here we review these insights, integrate them with existing knowledge about receptor function and try to understand how the structures relate to the key property of the AMPA receptor--its speed.

Original languageEnglish
Pages (from-to)195-205
Number of pages11
JournalBiological Chemistry
Volume397
Issue number3
Early online date31 Aug 2015
DOIs
Publication statusPublished - 1 Mar 2016
Externally publishedYes

Keywords

  • Animals
  • Glutamic Acid/metabolism
  • Humans
  • Kinetics
  • Models, Molecular
  • Mutation
  • Protein Conformation
  • Receptors, AMPA/chemistry
  • alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid/metabolism

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