How to build the fastest receptor on earth

Jelena Baranovic; Andrew J R Plested

doi:10.1515/hsz-2015-0182

How to build the fastest receptor on earth

Research output: Contribution to journal › Review article › peer-review

Abstract / Description of output

In 2014, a slew of structures of glutamate receptors were published, based on crystallography and electron microscopy. Here we review these insights, integrate them with existing knowledge about receptor function and try to understand how the structures relate to the key property of the AMPA receptor--its speed.

Original language	English
Pages (from-to)	195-205
Number of pages	11
Journal	Biological Chemistry
Volume	397
Issue number	3
Early online date	31 Aug 2015
DOIs	https://doi.org/10.1515/hsz-2015-0182
Publication status	Published - 1 Mar 2016
Externally published	Yes

Keywords / Materials (for Non-textual outputs)

Animals
Glutamic Acid/metabolism
Humans
Kinetics
Models, Molecular
Mutation
Protein Conformation
Receptors, AMPA/chemistry
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid/metabolism

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10.1515/hsz-2015-0182

Cite this

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title = "How to build the fastest receptor on earth",

abstract = "In 2014, a slew of structures of glutamate receptors were published, based on crystallography and electron microscopy. Here we review these insights, integrate them with existing knowledge about receptor function and try to understand how the structures relate to the key property of the AMPA receptor--its speed.",

keywords = "Animals, Glutamic Acid/metabolism, Humans, Kinetics, Models, Molecular, Mutation, Protein Conformation, Receptors, AMPA/chemistry, alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid/metabolism",

author = "Jelena Baranovic and Plested, {Andrew J R}",

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AU - Baranovic, Jelena

AU - Plested, Andrew J R

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KW - Animals

KW - Glutamic Acid/metabolism

KW - Humans

KW - Kinetics

KW - Models, Molecular

KW - Mutation

KW - Protein Conformation

KW - Receptors, AMPA/chemistry

KW - alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid/metabolism

U2 - 10.1515/hsz-2015-0182

DO - 10.1515/hsz-2015-0182

M3 - Review article

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SN - 1431-6730

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SP - 195

EP - 205

JO - Biological Chemistry

JF - Biological Chemistry

IS - 3

ER -

How to build the fastest receptor on earth

Abstract / Description of output

Keywords / Materials (for Non-textual outputs)

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