Human airway xenograft models of epithelial cell regeneration

Edith Puchelle, Bruno Peault

Research output: Contribution to journalLiterature reviewpeer-review

Abstract

Regeneration and restoration of the airway epithelium after mechanical, viral or bacterial injury have a determinant role in the evolution of numerous respiratory diseases such as chronic bronchitis, asthma and cystic fibrosis. The study in vivo of epithelial regeneration in animal models has shown that airway epithelial cells are able to dedifferentiate, spread, migrate over the denuded basement membrane and progressively redifferentiate to restore a functional respiratory epithelium after several weeks. Recently, human tracheal xenografts have been developed in immunodeficient severe combined immunodeficiency (SCID) and nude mice. In this review we recall that human airway cells implanted in such conditioned host grafts can regenerate a well-differentiated and functional human epithelium; we stress the interest in these humanized mice in assaying candidate progenitor and stem cells of the human airway mucosa.
Original languageEnglish
Pages (from-to)125-8
Number of pages4
JournalRespiratory research
Volume1
Issue number3
DOIs
Publication statusPublished - 12 Oct 2000

Keywords

  • airway cell differentiation
  • airway cell proliferation
  • human airway epithelium
  • Nude mouse
  • REGENERATION
  • SCID mouse
  • Stem Cells
  • xenograft

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