Human biliary epithelial cells from discarded donor livers rescue bile duct structure and function in a mouse model of biliary disease

John Hallett; Sofía Ferreira-Gonzalez; Janet Man; Alastair Kilpatrick; Hannah Esser; Kayleigh Thirwell; Mark Macmillan; Daniel Rodrigo Torres; Benjamin Dwyer; Victoria Gadd; Candice Ashmore-Harris; Wei-Yu Lu; John Thomson; Maurits Jansen; Eoghan O'Duibhir; Philip Starkey Lewis; Lara Campana; Rhona Aird; Thomas Bate; Alasdair R Fraser; John D M Campbell; Gabriel C Oniscu; David C Hay; Anthony Callanan; Stuart J Forbes

doi:10.1016/j.stem.2022.02.006

Human biliary epithelial cells from discarded donor livers rescue bile duct structure and function in a mouse model of biliary disease

John Hallett, Sofía Ferreira-Gonzalez, Janet Man, Alastair Kilpatrick, Hannah Esser, Kayleigh Thirwell, Mark Macmillan, Daniel Rodrigo Torres, Benjamin Dwyer, Victoria Gadd, Candice Ashmore-Harris, Wei-Yu Lu, John Thomson, Maurits Jansen, Eoghan O'Duibhir, Philip Starkey Lewis, Lara Campana, Rhona Aird, Thomas Bate, Alasdair R FraserJohn D M Campbell, Gabriel C Oniscu, David C Hay, Anthony Callanan, Stuart J Forbes

Research output: Contribution to journal › Article › peer-review

Original language	English
Journal	Cell Stem Cell
DOIs	https://doi.org/10.1016/j.stem.2022.02.006
Publication status	Published - 3 Mar 2022

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Hallett, J., Ferreira-Gonzalez, S., Man, J., Kilpatrick, A., Esser, H., Thirwell, K., Macmillan, M., Rodrigo Torres, D., Dwyer, B., Gadd, V., Ashmore-Harris, C., Lu, W-Y., Thomson, J., Jansen, M., O'Duibhir, E., Starkey Lewis, P., Campana, L., Aird, R., Bate, T., ... Forbes, S. J. (2022). Human biliary epithelial cells from discarded donor livers rescue bile duct structure and function in a mouse model of biliary disease. Cell Stem Cell. https://doi.org/10.1016/j.stem.2022.02.006

Hallett, John ; Ferreira-Gonzalez, Sofía ; Man, Janet ; Kilpatrick, Alastair ; Esser, Hannah ; Thirwell, Kayleigh ; Macmillan, Mark ; Rodrigo Torres, Daniel ; Dwyer, Benjamin ; Gadd, Victoria ; Ashmore-Harris, Candice ; Lu, Wei-Yu ; Thomson, John ; Jansen, Maurits ; O'Duibhir, Eoghan ; Starkey Lewis, Philip ; Campana, Lara ; Aird, Rhona ; Bate, Thomas ; Fraser, Alasdair R ; Campbell, John D M ; Oniscu, Gabriel C ; Hay, David C ; Callanan, Anthony ; Forbes, Stuart J. / Human biliary epithelial cells from discarded donor livers rescue bile duct structure and function in a mouse model of biliary disease. In: Cell Stem Cell. 2022.

@article{86bd932146854c01b4d3d9dbe210058d,

title = "Human biliary epithelial cells from discarded donor livers rescue bile duct structure and function in a mouse model of biliary disease",

author = "John Hallett and Sof{\'i}a Ferreira-Gonzalez and Janet Man and Alastair Kilpatrick and Hannah Esser and Kayleigh Thirwell and Mark Macmillan and {Rodrigo Torres}, Daniel and Benjamin Dwyer and Victoria Gadd and Candice Ashmore-Harris and Wei-Yu Lu and John Thomson and Maurits Jansen and Eoghan O'Duibhir and {Starkey Lewis}, Philip and Lara Campana and Rhona Aird and Thomas Bate and Fraser, {Alasdair R} and Campbell, {John D M} and Oniscu, {Gabriel C} and Hay, {David C} and Anthony Callanan and Forbes, {Stuart J}",

note = "Funding Information: This work was supported by the UK Medical Research Council. S.F.-G. T.Y.M. and K.T. were funded by Developmental Pathway Funding MRC, MR/P016839/1. J.M.H. was funded by the Edinburgh Clinical Academic Track Cancer Research UK PhD fellowship and the Edinburgh and Lothians Health Foundation Liver Transplant Fund. This work has made use of the resources provided by the Edinburgh Compute and Data Facility (ECDF). Conceptualization and design, J.M.H. S.F.-G. W.Y.-L. and S.J.F.; data generation, J.M.H. S.F.-G. T.Y.M. A.M.K. H.E. K.T. M.T.M. D.R.-T. B.J.D. V.L.G. C.A.-H. W.Y.-L. J.P.T. M.A.J. E.O. P.J.S.L. L.C. R.E.A. T.S.R.B. A.R.F. J.D.M.C. G.C.O. D.C.H. and A.C.; data analysis and interpretation, J.M.H. S.F.-G. B.J.D. K.T. J.P.T. A.M.K. W.Y.-L. E.O. M.A.J. D.R.-T. P.J.S.L. L.C. A.R.F. J.D.M.C. D.C.H. G.C.O. and S.J.F.; manuscript preparation, S.F.-.G.; writing – review & editing, S.F.-G. D.R.-T. A.M.K. and S.J.F.; funding acquisition, S.J.F. S.J.F. and J.D.M.C. are founders and scientific advisors of Resolution Therapeutics Ltd (not related to this study). D.C.H. is a founder, director, and shareholder at Stemnovate Limited and Stimuliver ApS (not related to this study). We worked to ensure gender balance in the recruitment of human subjects. We worked to ensure sex balance in the selection of non-human subjects. One or more of the authors of this paper self-identifies as a member of the LGBTQ+ community. One or more of the authors of this paper self-identifies as living with a disability. Funding Information: This work was supported by the UK Medical Research Council . S.F.-G., T.Y.M., and K.T. were funded by Developmental Pathway Funding MRC , MR/P016839/1 . J.M.H. was funded by the Edinburgh Clinical Academic Track Cancer Research UK PhD fellowship and the Edinburgh and Lothians Health Foundation Liver Transplant Fund . This work has made use of the resources provided by the Edinburgh Compute and Data Facility (ECDF). Publisher Copyright: {\textcopyright} 2022 The Authors",

year = "2022",

month = mar,

day = "3",

doi = "10.1016/j.stem.2022.02.006",

language = "English",

journal = "Cell Stem Cell",

issn = "1934-5909",

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}

Hallett, J , Ferreira-Gonzalez, S , Man, J , Kilpatrick, A , Esser, H, Thirwell, K, Macmillan, M , Rodrigo Torres, D, Dwyer, B, Gadd, V , Ashmore-Harris, C , Lu, W-Y , Thomson, J , Jansen, M, O'Duibhir, E, Starkey Lewis, P, Campana, L, Aird, R, Bate, T, Fraser, AR, Campbell, JDM, Oniscu, GC, Hay, DC , Callanan, A & Forbes, SJ 2022, 'Human biliary epithelial cells from discarded donor livers rescue bile duct structure and function in a mouse model of biliary disease', Cell Stem Cell. https://doi.org/10.1016/j.stem.2022.02.006

Human biliary epithelial cells from discarded donor livers rescue bile duct structure and function in a mouse model of biliary disease. / Hallett, John ; Ferreira-Gonzalez, Sofía ; Man, Janet ; Kilpatrick, Alastair ; Esser, Hannah; Thirwell, Kayleigh; Macmillan, Mark ; Rodrigo Torres, Daniel; Dwyer, Benjamin; Gadd, Victoria ; Ashmore-Harris, Candice ; Lu, Wei-Yu ; Thomson, John ; Jansen, Maurits; O'Duibhir, Eoghan; Starkey Lewis, Philip; Campana, Lara; Aird, Rhona; Bate, Thomas; Fraser, Alasdair R; Campbell, John D M; Oniscu, Gabriel C; Hay, David C ; Callanan, Anthony ; Forbes, Stuart J.

In: Cell Stem Cell, 03.03.2022.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Human biliary epithelial cells from discarded donor livers rescue bile duct structure and function in a mouse model of biliary disease

AU - Hallett, John

AU - Ferreira-Gonzalez, Sofía

AU - Man, Janet

AU - Kilpatrick, Alastair

AU - Esser, Hannah

AU - Thirwell, Kayleigh

AU - Macmillan, Mark

AU - Rodrigo Torres, Daniel

AU - Dwyer, Benjamin

AU - Gadd, Victoria

AU - Ashmore-Harris, Candice

AU - Lu, Wei-Yu

AU - Thomson, John

AU - Jansen, Maurits

AU - O'Duibhir, Eoghan

AU - Starkey Lewis, Philip

AU - Campana, Lara

AU - Aird, Rhona

AU - Bate, Thomas

AU - Fraser, Alasdair R

AU - Campbell, John D M

AU - Oniscu, Gabriel C

AU - Hay, David C

AU - Callanan, Anthony

AU - Forbes, Stuart J

N1 - Funding Information: This work was supported by the UK Medical Research Council. S.F.-G. T.Y.M. and K.T. were funded by Developmental Pathway Funding MRC, MR/P016839/1. J.M.H. was funded by the Edinburgh Clinical Academic Track Cancer Research UK PhD fellowship and the Edinburgh and Lothians Health Foundation Liver Transplant Fund. This work has made use of the resources provided by the Edinburgh Compute and Data Facility (ECDF). Conceptualization and design, J.M.H. S.F.-G. W.Y.-L. and S.J.F.; data generation, J.M.H. S.F.-G. T.Y.M. A.M.K. H.E. K.T. M.T.M. D.R.-T. B.J.D. V.L.G. C.A.-H. W.Y.-L. J.P.T. M.A.J. E.O. P.J.S.L. L.C. R.E.A. T.S.R.B. A.R.F. J.D.M.C. G.C.O. D.C.H. and A.C.; data analysis and interpretation, J.M.H. S.F.-G. B.J.D. K.T. J.P.T. A.M.K. W.Y.-L. E.O. M.A.J. D.R.-T. P.J.S.L. L.C. A.R.F. J.D.M.C. D.C.H. G.C.O. and S.J.F.; manuscript preparation, S.F.-.G.; writing – review & editing, S.F.-G. D.R.-T. A.M.K. and S.J.F.; funding acquisition, S.J.F. S.J.F. and J.D.M.C. are founders and scientific advisors of Resolution Therapeutics Ltd (not related to this study). D.C.H. is a founder, director, and shareholder at Stemnovate Limited and Stimuliver ApS (not related to this study). We worked to ensure gender balance in the recruitment of human subjects. We worked to ensure sex balance in the selection of non-human subjects. One or more of the authors of this paper self-identifies as a member of the LGBTQ+ community. One or more of the authors of this paper self-identifies as living with a disability. Funding Information: This work was supported by the UK Medical Research Council . S.F.-G., T.Y.M., and K.T. were funded by Developmental Pathway Funding MRC , MR/P016839/1 . J.M.H. was funded by the Edinburgh Clinical Academic Track Cancer Research UK PhD fellowship and the Edinburgh and Lothians Health Foundation Liver Transplant Fund . This work has made use of the resources provided by the Edinburgh Compute and Data Facility (ECDF). Publisher Copyright: © 2022 The Authors

PY - 2022/3/3

Y1 - 2022/3/3

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DO - 10.1016/j.stem.2022.02.006

M3 - Article

JO - Cell Stem Cell

JF - Cell Stem Cell

SN - 1934-5909

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