Human Cytomegalovirus Inhibitor AL18 Also Possesses Activity against Influenza A and B Viruses

Giulia Muratore; Beatrice Mercorelli; Laura Goracci; Gabriele Cruciani; Paul Digard; Giorgio Palu; Arianna Loregian

doi:10.1128/AAC.01219-12

Human Cytomegalovirus Inhibitor AL18 Also Possesses Activity against Influenza A and B Viruses

Giulia Muratore, Beatrice Mercorelli, Laura Goracci, Gabriele Cruciani, Paul Digard, Giorgio Palu, Arianna Loregian

Royal (Dick) School of Veterinary Studies

Research output: Contribution to journal › Article › peer-review

Abstract

AL18, an inhibitor of human cytomegalovirus DNA polymerase, was serendipitously found to also block the interaction between the PB1 and PA polymerase subunits of influenza A virus. Furthermore, AL18 effectively inhibited influenza A virus polymerase activity and the overall replication of influenza A and B viruses. A molecular model to explain the binding of AL18 to both cytomegalovirus and influenza targets is proposed. Thus, AL18 represents an interesting lead for the development of new antivirals.

Original language	English
Pages (from-to)	6009-6013
Number of pages	5
Journal	Antimicrobial Agents and Chemotherapy
Volume	56
Issue number	11
DOIs	https://doi.org/10.1128/AAC.01219-12
Publication status	Published - Nov 2012

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10.1128/AAC.01219-12

Human Cytomegalovirus Inhibitor AL18 Also Possesses Activity against Influenza A and B Viruses
Copyright © 2012, American Society for Microbiology. All Rights Reserved.
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http://aac.asm.org/content/56/11/6009

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abstract = "AL18, an inhibitor of human cytomegalovirus DNA polymerase, was serendipitously found to also block the interaction between the PB1 and PA polymerase subunits of influenza A virus. Furthermore, AL18 effectively inhibited influenza A virus polymerase activity and the overall replication of influenza A and B viruses. A molecular model to explain the binding of AL18 to both cytomegalovirus and influenza targets is proposed. Thus, AL18 represents an interesting lead for the development of new antivirals.",

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AU - Muratore, Giulia

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AU - Goracci, Laura

AU - Cruciani, Gabriele

AU - Digard, Paul

AU - Palu, Giorgio

AU - Loregian, Arianna

PY - 2012/11

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AB - AL18, an inhibitor of human cytomegalovirus DNA polymerase, was serendipitously found to also block the interaction between the PB1 and PA polymerase subunits of influenza A virus. Furthermore, AL18 effectively inhibited influenza A virus polymerase activity and the overall replication of influenza A and B viruses. A molecular model to explain the binding of AL18 to both cytomegalovirus and influenza targets is proposed. Thus, AL18 represents an interesting lead for the development of new antivirals.

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M3 - Article

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Human Cytomegalovirus Inhibitor AL18 Also Possesses Activity against Influenza A and B Viruses

Abstract

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