Human Cytomegalovirus Inhibitor AL18 Also Possesses Activity against Influenza A and B Viruses

Giulia Muratore, Beatrice Mercorelli, Laura Goracci, Gabriele Cruciani, Paul Digard, Giorgio Palu, Arianna Loregian

Research output: Contribution to journalArticlepeer-review

Abstract

AL18, an inhibitor of human cytomegalovirus DNA polymerase, was serendipitously found to also block the interaction between the PB1 and PA polymerase subunits of influenza A virus. Furthermore, AL18 effectively inhibited influenza A virus polymerase activity and the overall replication of influenza A and B viruses. A molecular model to explain the binding of AL18 to both cytomegalovirus and influenza targets is proposed. Thus, AL18 represents an interesting lead for the development of new antivirals.

Original languageEnglish
Pages (from-to)6009-6013
Number of pages5
JournalAntimicrobial Agents and Chemotherapy
Volume56
Issue number11
DOIs
Publication statusPublished - Nov 2012

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