Human epidermal growth factor receptor 2 status correlates with lymph node involvement in patients with estrogen receptor (ER) negative, but with grade in those with ER-positive early-stage breast cancer suitable for cytotoxic chemotherapy

John M S Bartlett; Ian O Ellis; Mitch Dowsett; Elizabeth A Mallon; David A Cameron; Stephen Johnston; Emma Hall; Roger A'Hern; Clare Peckitt; Judith M Bliss; Lindsay Johnson; Peter Barrett-Lee; Paul Ellis

doi:10.1200/JCO.2007.11.0973

Human epidermal growth factor receptor 2 status correlates with lymph node involvement in patients with estrogen receptor (ER) negative, but with grade in those with ER-positive early-stage breast cancer suitable for cytotoxic chemotherapy

John M S Bartlett, Ian O Ellis, Mitch Dowsett, Elizabeth A Mallon, David A Cameron, Stephen Johnston, Emma Hall, Roger A'Hern, Clare Peckitt, Judith M Bliss, Lindsay Johnson, Peter Barrett-Lee, Paul Ellis

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

Human epidermal growth factor receptor 2 (HER-2) expression is associated with increased risk of high-grade disease, nodal metastasis, and absence of estrogen receptors (ERs) in early breast cancer. We tested interactions between ER and HER-2 to determine if they may modulate breast cancer nodal metastasis and proliferation.

Original language	English
Pages (from-to)	4423-30
Number of pages	8
Journal	Journal of Clinical Oncology
Volume	25
Issue number	28
DOIs	https://doi.org/10.1200/JCO.2007.11.0973
Publication status	Published - 1 Oct 2007

Keywords / Materials (for Non-textual outputs)

Adult
Antineoplastic Combined Chemotherapy Protocols
Breast Neoplasms
Female
Humans
Logistic Models
Lymphatic Metastasis
Middle Aged
Multivariate Analysis
Receptor, erbB-2
Receptors, Estrogen
Receptors, Progesterone
Sensitivity and Specificity

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10.1200/JCO.2007.11.0973

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Bartlett, J. M. S., Ellis, I. O., Dowsett, M., Mallon, E. A., Cameron, D. A., Johnston, S., Hall, E., A'Hern, R., Peckitt, C., Bliss, J. M., Johnson, L., Barrett-Lee, P., & Ellis, P. (2007). Human epidermal growth factor receptor 2 status correlates with lymph node involvement in patients with estrogen receptor (ER) negative, but with grade in those with ER-positive early-stage breast cancer suitable for cytotoxic chemotherapy. Journal of Clinical Oncology, 25(28), 4423-30. https://doi.org/10.1200/JCO.2007.11.0973

Bartlett, John M S ; Ellis, Ian O ; Dowsett, Mitch et al. / Human epidermal growth factor receptor 2 status correlates with lymph node involvement in patients with estrogen receptor (ER) negative, but with grade in those with ER-positive early-stage breast cancer suitable for cytotoxic chemotherapy. In: Journal of Clinical Oncology. 2007 ; Vol. 25, No. 28. pp. 4423-30.

@article{21ea39c9a73142a1a285fdac031b6160,

title = "Human epidermal growth factor receptor 2 status correlates with lymph node involvement in patients with estrogen receptor (ER) negative, but with grade in those with ER-positive early-stage breast cancer suitable for cytotoxic chemotherapy",

abstract = "Human epidermal growth factor receptor 2 (HER-2) expression is associated with increased risk of high-grade disease, nodal metastasis, and absence of estrogen receptors (ERs) in early breast cancer. We tested interactions between ER and HER-2 to determine if they may modulate breast cancer nodal metastasis and proliferation.",

keywords = "Adult, Antineoplastic Combined Chemotherapy Protocols, Breast Neoplasms, Female, Humans, Logistic Models, Lymphatic Metastasis, Middle Aged, Multivariate Analysis, Receptor, erbB-2, Receptors, Estrogen, Receptors, Progesterone, Sensitivity and Specificity",

author = "Bartlett, {John M S} and Ellis, {Ian O} and Mitch Dowsett and Mallon, {Elizabeth A} and Cameron, {David A} and Stephen Johnston and Emma Hall and Roger A'Hern and Clare Peckitt and Bliss, {Judith M} and Lindsay Johnson and Peter Barrett-Lee and Paul Ellis",

year = "2007",

month = oct,

day = "1",

doi = "10.1200/JCO.2007.11.0973",

language = "English",

volume = "25",

pages = "4423--30",

journal = "Journal of Clinical Oncology",

issn = "0732-183X",

publisher = "American Society of Clinical Oncology",

number = "28",

}

Bartlett, JMS, Ellis, IO, Dowsett, M, Mallon, EA, Cameron, DA, Johnston, S, Hall, E, A'Hern, R, Peckitt, C, Bliss, JM, Johnson, L, Barrett-Lee, P & Ellis, P 2007, 'Human epidermal growth factor receptor 2 status correlates with lymph node involvement in patients with estrogen receptor (ER) negative, but with grade in those with ER-positive early-stage breast cancer suitable for cytotoxic chemotherapy', Journal of Clinical Oncology, vol. 25, no. 28, pp. 4423-30. https://doi.org/10.1200/JCO.2007.11.0973

Human epidermal growth factor receptor 2 status correlates with lymph node involvement in patients with estrogen receptor (ER) negative, but with grade in those with ER-positive early-stage breast cancer suitable for cytotoxic chemotherapy. / Bartlett, John M S; Ellis, Ian O; Dowsett, Mitch et al.
In: Journal of Clinical Oncology, Vol. 25, No. 28, 01.10.2007, p. 4423-30.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Human epidermal growth factor receptor 2 status correlates with lymph node involvement in patients with estrogen receptor (ER) negative, but with grade in those with ER-positive early-stage breast cancer suitable for cytotoxic chemotherapy

AU - Bartlett, John M S

AU - Ellis, Ian O

AU - Dowsett, Mitch

AU - Mallon, Elizabeth A

AU - Cameron, David A

AU - Johnston, Stephen

AU - Hall, Emma

AU - A'Hern, Roger

AU - Peckitt, Clare

AU - Bliss, Judith M

AU - Johnson, Lindsay

AU - Barrett-Lee, Peter

AU - Ellis, Paul

PY - 2007/10/1

Y1 - 2007/10/1

N2 - Human epidermal growth factor receptor 2 (HER-2) expression is associated with increased risk of high-grade disease, nodal metastasis, and absence of estrogen receptors (ERs) in early breast cancer. We tested interactions between ER and HER-2 to determine if they may modulate breast cancer nodal metastasis and proliferation.

AB - Human epidermal growth factor receptor 2 (HER-2) expression is associated with increased risk of high-grade disease, nodal metastasis, and absence of estrogen receptors (ERs) in early breast cancer. We tested interactions between ER and HER-2 to determine if they may modulate breast cancer nodal metastasis and proliferation.

KW - Adult

KW - Antineoplastic Combined Chemotherapy Protocols

KW - Breast Neoplasms

KW - Female

KW - Humans

KW - Logistic Models

KW - Lymphatic Metastasis

KW - Middle Aged

KW - Multivariate Analysis

KW - Receptor, erbB-2

KW - Receptors, Estrogen

KW - Receptors, Progesterone

KW - Sensitivity and Specificity

U2 - 10.1200/JCO.2007.11.0973

DO - 10.1200/JCO.2007.11.0973

M3 - Article

C2 - 17906205

SN - 0732-183X

VL - 25

SP - 4423

EP - 4430

JO - Journal of Clinical Oncology

JF - Journal of Clinical Oncology

IS - 28

ER -

Bartlett JMS, Ellis IO, Dowsett M, Mallon EA, Cameron DA, Johnston S et al. Human epidermal growth factor receptor 2 status correlates with lymph node involvement in patients with estrogen receptor (ER) negative, but with grade in those with ER-positive early-stage breast cancer suitable for cytotoxic chemotherapy. Journal of Clinical Oncology. 2007 Oct 1;25(28):4423-30. doi: 10.1200/JCO.2007.11.0973