Human Germ line Genetic Modification: Scientific and Bioethical Perspectives

Kevin R. Smith*, Sarah Chan, John Harris

*Corresponding author for this work

Research output: Contribution to journalLiterature reviewpeer-review

Abstract

The latest mammalian genetic modification technology offers efficient and reliable targeting of genomic sequences, in the guise of designer genetic recombination tools. These and other improvements in genetic engineering technology suggest that human germline genetic modification (HGGM) will become a safe and effective prospect in the relatively near future. Several substantive ethical objections have been raised against HGGM including claims of unacceptably high levels of risk, damage to the status of future persons, and violations of justice and autonomy. This paper critically reviews the latest GM science and discusses the key ethical objections to HGGM. We conclude that major benefits are likely to accrue through the use of safe and effective HGGM and that it would thus be unethical to take a precautionary stance Against HGGM. (C) 2012 IMSS. Published by Elsevier Inc.

Original languageEnglish
Pages (from-to)491-513
Number of pages23
JournalArchives of medical research
Volume43
Issue number7
DOIs
Publication statusPublished - 13 Oct 2012

Keywords

  • Human germline
  • Genetic modification
  • Gene targeting
  • Gene therapy
  • Genetic enhancement
  • Genethics
  • ZINC-FINGER NUCLEASES
  • EMBRYONIC STEM-CELLS
  • TRIPLEX-FORMING OLIGONUCLEOTIDES
  • INTRACYTOPLASMIC SPERM INJECTION
  • TISSUE-SPECIFIC EXPRESSION
  • RNA-DNA OLIGONUCLEOTIDES
  • HOMOLOGOUS RECOMBINATION
  • TRANSGENIC MICE
  • PRECAUTIONARY PRINCIPLE
  • MAMMALIAN-CELLS

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