Human hepatic HepaRG cells maintain an organotypic phenotype with high intrinsic CYP450 activity/metabolism and significantly outperform standard HepG2/C3A cells for pharmaceutical and therapeutic applications

Leonard Nelson; Katie Morgan; Philipp Treskes; Kay Samuel; Catherine J Henderson; Claire LeBled; Natalie Homer; M Helen Grant; Peter C. Hayes; John Plevris

doi:10.1111/bcpt.12631

Human hepatic HepaRG cells maintain an organotypic phenotype with high intrinsic CYP450 activity/metabolism and significantly outperform standard HepG2/C3A cells for pharmaceutical and therapeutic applications

Leonard Nelson, Katie Morgan, Philipp Treskes, Kay Samuel, Catherine J Henderson, Claire LeBled, Natalie Homer, M Helen Grant, Peter C. Hayes, John Plevris

Research output: Contribution to journal › Article › peer-review

Original language	English
Journal	Basic and Clinical Pharmacology and Toxicology
Early online date	10 Jun 2016
DOIs	https://doi.org/10.1111/bcpt.12631
Publication status	E-pub ahead of print - 10 Jun 2016

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10.1111/bcpt.12631

Nelson_et_al-2016-Basic_&_Clinical_Pharmacology_&_Toxicology
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Accepted author manuscript, 3.36 MB

Nanopatterned Human Liver BioChips for Drug Hepatotoxicity Screening
Hayes, P.
BBSRC
1/07/14 → 30/09/16
Project: Research

Natalie Homer
- Centre for Cardiovascular Science
- Deanery of Clinical Sciences - Senior Research Fellow
Person: Academic: Research Active (Research Assistant)

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Nelson, L., Morgan, K., Treskes, P., Samuel, K., Henderson, C. J., LeBled, C., Homer, N., Grant, M. H., Hayes, P. C., & Plevris, J. (2016). Human hepatic HepaRG cells maintain an organotypic phenotype with high intrinsic CYP450 activity/metabolism and significantly outperform standard HepG2/C3A cells for pharmaceutical and therapeutic applications. Basic and Clinical Pharmacology and Toxicology. Advance online publication. https://doi.org/10.1111/bcpt.12631

@article{ee02b9d4c543456cb84879ce12068563,

title = "Human hepatic HepaRG cells maintain an organotypic phenotype with high intrinsic CYP450 activity/metabolism and significantly outperform standard HepG2/C3A cells for pharmaceutical and therapeutic applications",

author = "Leonard Nelson and Katie Morgan and Philipp Treskes and Kay Samuel and Henderson, {Catherine J} and Claire LeBled and Natalie Homer and Grant, {M Helen} and Hayes, {Peter C.} and John Plevris",

year = "2016",

month = jun,

day = "10",

doi = "10.1111/bcpt.12631",

language = "English",

journal = "Basic and Clinical Pharmacology and Toxicology",

issn = "1742-7835",

publisher = "Wiley-Blackwell",

}

Nelson, L, Morgan, K, Treskes, P, Samuel, K, Henderson, CJ, LeBled, C, Homer, N, Grant, MH, Hayes, PC & Plevris, J 2016, 'Human hepatic HepaRG cells maintain an organotypic phenotype with high intrinsic CYP450 activity/metabolism and significantly outperform standard HepG2/C3A cells for pharmaceutical and therapeutic applications', Basic and Clinical Pharmacology and Toxicology. https://doi.org/10.1111/bcpt.12631

Human hepatic HepaRG cells maintain an organotypic phenotype with high intrinsic CYP450 activity/metabolism and significantly outperform standard HepG2/C3A cells for pharmaceutical and therapeutic applications. / Nelson, Leonard; Morgan, Katie; Treskes, Philipp et al.
In: Basic and Clinical Pharmacology and Toxicology, 10.06.2016.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Human hepatic HepaRG cells maintain an organotypic phenotype with high intrinsic CYP450 activity/metabolism and significantly outperform standard HepG2/C3A cells for pharmaceutical and therapeutic applications

AU - Nelson, Leonard

AU - Morgan, Katie

AU - Treskes, Philipp

AU - Samuel, Kay

AU - Henderson, Catherine J

AU - LeBled, Claire

AU - Homer, Natalie

AU - Grant, M Helen

AU - Hayes, Peter C.

AU - Plevris, John

PY - 2016/6/10

Y1 - 2016/6/10

U2 - 10.1111/bcpt.12631

DO - 10.1111/bcpt.12631

M3 - Article

SN - 1742-7835

JO - Basic and Clinical Pharmacology and Toxicology

JF - Basic and Clinical Pharmacology and Toxicology

ER -

Nelson L, Morgan K, Treskes P, Samuel K, Henderson CJ, LeBled C et al. Human hepatic HepaRG cells maintain an organotypic phenotype with high intrinsic CYP450 activity/metabolism and significantly outperform standard HepG2/C3A cells for pharmaceutical and therapeutic applications. Basic and Clinical Pharmacology and Toxicology. 2016 Jun 10. Epub 2016 Jun 10. doi: 10.1111/bcpt.12631

Human hepatic HepaRG cells maintain an organotypic phenotype with high intrinsic CYP450 activity/metabolism and significantly outperform standard HepG2/C3A cells for pharmaceutical and therapeutic applications

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Projects

Nanopatterned Human Liver BioChips for Drug Hepatotoxicity Screening

Profiles

Natalie Homer

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