Human intestinal tissue tropism of intimin epsilon O103 Escherichia coli

R J  Fitzhenry; M P  Stevens; C  Jenkins; T S  Wallis; R  Heuschkel; S  Murch; M  Thomson; G  Frankel; A D  Phillips

doi:10.1016/S0378-1097(02)01182-5

Human intestinal tissue tropism of intimin epsilon O103 Escherichia coli

R J Fitzhenry, M P Stevens, C Jenkins, T S Wallis, R Heuschkel, S Murch, M Thomson, G Frankel, A D Phillips

Royal (Dick) School of Veterinary Studies

Research output: Contribution to journal › Article › peer-review

Abstract

Human intestinal in vitro organ culture was used to assess the tissue tropism of human isolates of Escherichia coli O103:H2 and O103:H- that express intimin F. Both strains showed tropism for follicle associated epithelium and limited adhesion to other regions of the small and large intestine. This is similar to the tissue tropism shown by intimin gamma enterohaemorrhagic (EHEC) O157:H7, but distinct from that of intimin a enteropathogenic (EPEC) O127:H6. (C) 2002 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved.

Original language	English
Pages (from-to)	311-316
Number of pages	6
Journal	FEMS Microbiology Letters
Volume	218
Issue number	2
DOIs	https://doi.org/10.1016/S0378-1097(02)01182-5
Publication status	Published - 28 Jan 2003

Keywords

Amino Acid Sequence
Cloning, Molecular
Escherichia coli
Escherichia coli Proteins
Humans
Intestines/cytology
Intestines/metabolism
Intestines/microbiology
Intestines/ultrastructure
Molecular Sequence Data
Mutation
Organ Culture Techniques
Phylogeny
Receptors, Cell Surface
Tropism

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10.1016/S0378-1097(02)01182-5

Human intestinal tissue tropism of intimin epsilon O103 Escherichia Coli
Copyright 2002 Federation of European Microbiological Societies
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http://onlinelibrary.wiley.com/doi/10.1016/S0378-1097(02)01182-5/abstract

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title = "Human intestinal tissue tropism of intimin epsilon O103 Escherichia coli",

abstract = "Human intestinal in vitro organ culture was used to assess the tissue tropism of human isolates of Escherichia coli O103:H2 and O103:H- that express intimin F. Both strains showed tropism for follicle associated epithelium and limited adhesion to other regions of the small and large intestine. This is similar to the tissue tropism shown by intimin gamma enterohaemorrhagic (EHEC) O157:H7, but distinct from that of intimin a enteropathogenic (EPEC) O127:H6. (C) 2002 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved.",

keywords = "Amino Acid Sequence, Cloning, Molecular, Escherichia coli, Escherichia coli Proteins, Humans, Intestines/cytology, Intestines/metabolism, Intestines/microbiology, Intestines/ultrastructure, Molecular Sequence Data, Mutation, Organ Culture Techniques, Phylogeny, Receptors, Cell Surface, Tropism",

author = "Fitzhenry, {R J} and Stevens, {M P} and C Jenkins and Wallis, {T S} and R Heuschkel and S Murch and M Thomson and G Frankel and Phillips, {A D}",

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T1 - Human intestinal tissue tropism of intimin epsilon O103 Escherichia coli

AU - Fitzhenry, R J

AU - Stevens, M P

AU - Jenkins, C

AU - Wallis, T S

AU - Heuschkel, R

AU - Murch, S

AU - Thomson, M

AU - Frankel, G

AU - Phillips, A D

PY - 2003/1/28

Y1 - 2003/1/28

N2 - Human intestinal in vitro organ culture was used to assess the tissue tropism of human isolates of Escherichia coli O103:H2 and O103:H- that express intimin F. Both strains showed tropism for follicle associated epithelium and limited adhesion to other regions of the small and large intestine. This is similar to the tissue tropism shown by intimin gamma enterohaemorrhagic (EHEC) O157:H7, but distinct from that of intimin a enteropathogenic (EPEC) O127:H6. (C) 2002 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved.

AB - Human intestinal in vitro organ culture was used to assess the tissue tropism of human isolates of Escherichia coli O103:H2 and O103:H- that express intimin F. Both strains showed tropism for follicle associated epithelium and limited adhesion to other regions of the small and large intestine. This is similar to the tissue tropism shown by intimin gamma enterohaemorrhagic (EHEC) O157:H7, but distinct from that of intimin a enteropathogenic (EPEC) O127:H6. (C) 2002 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved.

KW - Amino Acid Sequence

KW - Cloning, Molecular

KW - Escherichia coli

KW - Escherichia coli Proteins

KW - Humans

KW - Intestines/cytology

KW - Intestines/metabolism

KW - Intestines/microbiology

KW - Intestines/ultrastructure

KW - Molecular Sequence Data

KW - Mutation

KW - Organ Culture Techniques

KW - Phylogeny

KW - Receptors, Cell Surface

KW - Tropism

U2 - 10.1016/S0378-1097(02)01182-5

DO - 10.1016/S0378-1097(02)01182-5

M3 - Article

VL - 218

SP - 311

EP - 316

JO - FEMS Microbiology Letters

JF - FEMS Microbiology Letters

SN - 0378-1097

IS - 2

ER -

Human intestinal tissue tropism of intimin epsilon O103 Escherichia coli

Abstract

Keywords

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