Human intestinal tissue tropism of intimin epsilon O103 Escherichia coli

R J Fitzhenry, M P Stevens, C Jenkins, T S Wallis, R Heuschkel, S Murch, M Thomson, G Frankel, A D Phillips

Research output: Contribution to journalArticlepeer-review


Human intestinal in vitro organ culture was used to assess the tissue tropism of human isolates of Escherichia coli O103:H2 and O103:H- that express intimin F. Both strains showed tropism for follicle associated epithelium and limited adhesion to other regions of the small and large intestine. This is similar to the tissue tropism shown by intimin gamma enterohaemorrhagic (EHEC) O157:H7, but distinct from that of intimin a enteropathogenic (EPEC) O127:H6. (C) 2002 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved.

Original languageEnglish
Pages (from-to)311-316
Number of pages6
JournalFEMS Microbiology Letters
Issue number2
Publication statusPublished - 28 Jan 2003


  • Amino Acid Sequence
  • Cloning, Molecular
  • Escherichia coli
  • Escherichia coli Proteins
  • Humans
  • Intestines/cytology
  • Intestines/metabolism
  • Intestines/microbiology
  • Intestines/ultrastructure
  • Molecular Sequence Data
  • Mutation
  • Organ Culture Techniques
  • Phylogeny
  • Receptors, Cell Surface
  • Tropism


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