Human neutrophil elastase inhibitors in innate and adaptive immunity

P M Fitch, A Roghanian, S E M Howie, J-M Sallenave

Research output: Contribution to journalArticlepeer-review


Recent evidence shows that human neutrophil elastase inhibitors can be synthesized locally at mucosal sites. In addition to efficiently targeting bacterial and host enzymes, they can be released in the interstitium and in the lumen of mucosa, where they have been shown to have antimicrobial activities, and to activate innate immune responses. This review will address more particularly the pleiotropic functions of low-molecular-mass neutrophil elastase inhibitors [SLPI (secretory leucocyte proteinase inhibitor) and elafin] and, more specifically, their role in the development of the adaptive immune response.
Original languageEnglish
Pages (from-to)279-82
Number of pages4
JournalBiochemical Society Transactions
Issue numberPt 2
Publication statusPublished - 2006


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