Human papillomavirus in carcinomas of the sinonasal tract

S.J. Brown, M. Kwiatkowski, O.F. Allsobrook, Kate Cuschieri, S.J. Thavaraj

Research output: Contribution to conferenceAbstractpeer-review


Background / Objectives
High-risk HPV (HR HPV) is an established causative factor for oropharyngeal carcinomas, but in recent times there has been increasing evidence of the role for HPV in non -oropharyngeal head and neck cancers including those arising in the sinonasal tract. However, the prevalence and clinical significance of HPV -associated sinonasal cancer are poorly understood. This study aims to determine the preval
ence of HR HPV infection in a cohort of sinonasal carcinomas (SNC) and whether this status impacts overall patient survival.
132 patients diagnosed with sinonasal carcinoma between October 2000 and March 2018 were identified from the pathology archive of a single UK tertiary referral centre. Residual tissue was available for testing for 124 cases, where p16 immunohistochemistry was performed and, if positive, DNA in situ hybridisation for HR HPV types was undertaken. Molecular genotyping using a PCR and luminex based strategy was also performed on a representative sub-cohort. Overall survival was determined from electronic patient records.
Of the 132 cases, 124 sinonasal carcinomas were available for HPV testing. 14% were positive for p16 and HR HPV DNA by in situ hybridization. All of these cases showed strong reactivity for p16 immunohistochemistry. The HPV-related carcinomas occurred in 12 men and 5 women with an age range of 29 to 82 (Mean. 53 y). They consisted of 11 squamous cell carcinomas (including one papillary type), and one each of small cell neuroendocrine carcinoma, adenoid cystic carcinoma, and 255/324 adenocarcinoma. A further 3 HPV positive carcinomas were difficult to classify according to current histopathological criteria. Follow up data was retrievable for 100 patients (including 16 HR-HPV positive). Kaplan-Meier plot for overall survival outcome is demonstrated in the figure below. There was no significant difference in overall survival between the patients with HPV positive and negative carcinomas (Chi square 0.267, p=0.605)
Original languageEnglish
Publication statusPublished - Dec 2018
EventEUROGIN 2018 - From control to elimination of HPV induced cancers - Lisbon, Portugal
Duration: 2 Dec 20185 Dec 2018


ConferenceEUROGIN 2018 - From control to elimination of HPV induced cancers
Abbreviated titleEurogin 2018
Internet address

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