Human papillomavirus type 18 is associated with less apoptosis in fibroblast tumours than human papillomavirus type 16

M J Arends; A H Wyllie; C C Bird

Human papillomavirus type 18 is associated with less apoptosis in fibroblast tumours than human papillomavirus type 16

M J Arends, A H Wyllie, C C Bird

Deanery of Molecular, Genetic and Population Health Sciences

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

In human cervical neoplasia human papillomavirus (HPV) type 18 has a higher cancer/cervical intraepithelial neoplasia (CIN) prevalence ratio than HPV 16. Fibrosarcomas derived from rat fibroblasts transfected with HPV 16 or 18 genomes showed increased apoptosis compared with controls. However, HPV 18 was associated with significantly less apoptosis than HPV 16, affording one possible explanation for the more rapidly progressive cervical neoplasia associated with HPV 18.

Original language	English
Pages (from-to)	646-9
Number of pages	4
Journal	British Journal of Cancer
Volume	72
Issue number	3
Publication status	Published - Sept 1995

Keywords / Materials (for Non-textual outputs)

Animals
Apoptosis
Fibrosarcoma
Genome, Viral
Humans
Lung Neoplasms
Mice
Mice, Inbred CBA
Oncogene Proteins, Viral
Papillomaviridae
Papillomavirus Infections
Rats
Rats, Inbred F344
Transfection
Tumor Cells, Cultured
Tumor Virus Infections

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Human papillomavirus type 18 is associated with less apoptosis in fibroblast tumours than human papillomavirus type 16
1995 Stockton Press
Final published version, 735 KB

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2033887/

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title = "Human papillomavirus type 18 is associated with less apoptosis in fibroblast tumours than human papillomavirus type 16",

abstract = "In human cervical neoplasia human papillomavirus (HPV) type 18 has a higher cancer/cervical intraepithelial neoplasia (CIN) prevalence ratio than HPV 16. Fibrosarcomas derived from rat fibroblasts transfected with HPV 16 or 18 genomes showed increased apoptosis compared with controls. However, HPV 18 was associated with significantly less apoptosis than HPV 16, affording one possible explanation for the more rapidly progressive cervical neoplasia associated with HPV 18.",

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author = "Arends, {M J} and Wyllie, {A H} and Bird, {C C}",

year = "1995",

month = sep,

language = "English",

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pages = "646--9",

journal = "British Journal of Cancer",

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T1 - Human papillomavirus type 18 is associated with less apoptosis in fibroblast tumours than human papillomavirus type 16

AU - Arends, M J

AU - Wyllie, A H

AU - Bird, C C

PY - 1995/9

Y1 - 1995/9

N2 - In human cervical neoplasia human papillomavirus (HPV) type 18 has a higher cancer/cervical intraepithelial neoplasia (CIN) prevalence ratio than HPV 16. Fibrosarcomas derived from rat fibroblasts transfected with HPV 16 or 18 genomes showed increased apoptosis compared with controls. However, HPV 18 was associated with significantly less apoptosis than HPV 16, affording one possible explanation for the more rapidly progressive cervical neoplasia associated with HPV 18.

AB - In human cervical neoplasia human papillomavirus (HPV) type 18 has a higher cancer/cervical intraepithelial neoplasia (CIN) prevalence ratio than HPV 16. Fibrosarcomas derived from rat fibroblasts transfected with HPV 16 or 18 genomes showed increased apoptosis compared with controls. However, HPV 18 was associated with significantly less apoptosis than HPV 16, affording one possible explanation for the more rapidly progressive cervical neoplasia associated with HPV 18.

KW - Animals

KW - Apoptosis

KW - Fibrosarcoma

KW - Genome, Viral

KW - Humans

KW - Lung Neoplasms

KW - Mice

KW - Mice, Inbred CBA

KW - Oncogene Proteins, Viral

KW - Papillomaviridae

KW - Papillomavirus Infections

KW - Rats

KW - Rats, Inbred F344

KW - Transfection

KW - Tumor Cells, Cultured

KW - Tumor Virus Infections

M3 - Article

C2 - 7669576

SN - 0007-0920

VL - 72

SP - 646

EP - 649

JO - British Journal of Cancer

JF - British Journal of Cancer

IS - 3

ER -

Human papillomavirus type 18 is associated with less apoptosis in fibroblast tumours than human papillomavirus type 16

Abstract / Description of output

Keywords / Materials (for Non-textual outputs)

Access to Document

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Cite this