Human Placenta Is a Potent Hematopoietic Niche Containing Hematopoietic Stem and Progenitor Cells throughout Development

Catherine Robin; Karine Bollerot; Sandra Mendes; Esther Haak; Mihaela Crisan; Francesco Cerisoli; Ivoune Lauw; Polynikis Kaimakis; Ruud Jorna; Mark Vermeulen; Manfred Kayser; Reinier Van Der Linden; Parisa Imanirad; Monique Verstegen; Humaira Nawaz-yousaf; Natalie Papazian; Eric Steegers; Tom Cupedo; Elaine Dzierzak

doi:10.1016/j.stem.2009.08.020

Human Placenta Is a Potent Hematopoietic Niche Containing Hematopoietic Stem and Progenitor Cells throughout Development

Catherine Robin, Karine Bollerot, Sandra Mendes, Esther Haak, Mihaela Crisan, Francesco Cerisoli, Ivoune Lauw, Polynikis Kaimakis, Ruud Jorna, Mark Vermeulen, Manfred Kayser, Reinier Van Der Linden, Parisa Imanirad, Monique Verstegen, Humaira Nawaz-yousaf, Natalie Papazian, Eric Steegers, Tom Cupedo, Elaine Dzierzak

Research output: Contribution to journal › Article › peer-review

Abstract

Hematopoietic stem cells (HSCs) are responsible for the life-long production of the blood system and are pivotal cells in hematologic transplantation therapies. During mouse and human development, the first HSCs are produced in the aorta-gonad-mesonephros region. Subsequent to this emergence, HSCs are found in other anatomical sites of the mouse conceptus. While the mouse placenta contains abundant HSCs at midgestation, little is known concerning whether HSCs or hematopoietic progenitors are present and supported in the human placenta during development. In this study we show, over a range of developmental times including term, that the human placenta contains hematopoietic progenitors and HSCs. Moreover, stromal cell lines generated from human placenta at several developmental time points are pericyte-like cells and support human hematopoiesis. Immunostaining of placenta sections during development localizes hematopoietic cells in close contact with pericytes/perivascular cells. Thus, the human placenta is a potent hematopoietic niche throughout development.

Original language	English
Pages (from-to)	385-395
Journal	Cell Stem Cell
Volume	5
Issue number	4
DOIs	https://doi.org/10.1016/j.stem.2009.08.020
Publication status	Published - 1 Oct 2009

Keywords

STEMCELL

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10.1016/j.stem.2009.08.020

http://www.sciencedirect.com/science/article/pii/S1934590909004445

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Robin, C., Bollerot, K., Mendes, S., Haak, E., Crisan, M., Cerisoli, F., Lauw, I., Kaimakis, P., Jorna, R., Vermeulen, M., Kayser, M., Van Der Linden, R., Imanirad, P., Verstegen, M., Nawaz-yousaf, H., Papazian, N., Steegers, E., Cupedo, T., & Dzierzak, E. (2009). Human Placenta Is a Potent Hematopoietic Niche Containing Hematopoietic Stem and Progenitor Cells throughout Development. Cell Stem Cell, 5(4), 385-395. https://doi.org/10.1016/j.stem.2009.08.020

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title = "Human Placenta Is a Potent Hematopoietic Niche Containing Hematopoietic Stem and Progenitor Cells throughout Development",

abstract = "Hematopoietic stem cells (HSCs) are responsible for the life-long production of the blood system and are pivotal cells in hematologic transplantation therapies. During mouse and human development, the first HSCs are produced in the aorta-gonad-mesonephros region. Subsequent to this emergence, HSCs are found in other anatomical sites of the mouse conceptus. While the mouse placenta contains abundant HSCs at midgestation, little is known concerning whether HSCs or hematopoietic progenitors are present and supported in the human placenta during development. In this study we show, over a range of developmental times including term, that the human placenta contains hematopoietic progenitors and HSCs. Moreover, stromal cell lines generated from human placenta at several developmental time points are pericyte-like cells and support human hematopoiesis. Immunostaining of placenta sections during development localizes hematopoietic cells in close contact with pericytes/perivascular cells. Thus, the human placenta is a potent hematopoietic niche throughout development. ",

keywords = "STEMCELL",

author = "Catherine Robin and Karine Bollerot and Sandra Mendes and Esther Haak and Mihaela Crisan and Francesco Cerisoli and Ivoune Lauw and Polynikis Kaimakis and Ruud Jorna and Mark Vermeulen and Manfred Kayser and {Van Der Linden}, Reinier and Parisa Imanirad and Monique Verstegen and Humaira Nawaz-yousaf and Natalie Papazian and Eric Steegers and Tom Cupedo and Elaine Dzierzak",

year = "2009",

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doi = "10.1016/j.stem.2009.08.020",

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Robin, C, Bollerot, K, Mendes, S, Haak, E, Crisan, M, Cerisoli, F, Lauw, I, Kaimakis, P, Jorna, R, Vermeulen, M, Kayser, M, Van Der Linden, R, Imanirad, P, Verstegen, M, Nawaz-yousaf, H, Papazian, N, Steegers, E, Cupedo, T & Dzierzak, E 2009, 'Human Placenta Is a Potent Hematopoietic Niche Containing Hematopoietic Stem and Progenitor Cells throughout Development', Cell Stem Cell, vol. 5, no. 4, pp. 385-395. https://doi.org/10.1016/j.stem.2009.08.020

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T1 - Human Placenta Is a Potent Hematopoietic Niche Containing Hematopoietic Stem and Progenitor Cells throughout Development

AU - Robin, Catherine

AU - Bollerot, Karine

AU - Mendes, Sandra

AU - Haak, Esther

AU - Crisan, Mihaela

AU - Cerisoli, Francesco

AU - Lauw, Ivoune

AU - Kaimakis, Polynikis

AU - Jorna, Ruud

AU - Vermeulen, Mark

AU - Kayser, Manfred

AU - Van Der Linden, Reinier

AU - Imanirad, Parisa

AU - Verstegen, Monique

AU - Nawaz-yousaf, Humaira

AU - Papazian, Natalie

AU - Steegers, Eric

AU - Cupedo, Tom

AU - Dzierzak, Elaine

PY - 2009/10/1

Y1 - 2009/10/1

N2 - Hematopoietic stem cells (HSCs) are responsible for the life-long production of the blood system and are pivotal cells in hematologic transplantation therapies. During mouse and human development, the first HSCs are produced in the aorta-gonad-mesonephros region. Subsequent to this emergence, HSCs are found in other anatomical sites of the mouse conceptus. While the mouse placenta contains abundant HSCs at midgestation, little is known concerning whether HSCs or hematopoietic progenitors are present and supported in the human placenta during development. In this study we show, over a range of developmental times including term, that the human placenta contains hematopoietic progenitors and HSCs. Moreover, stromal cell lines generated from human placenta at several developmental time points are pericyte-like cells and support human hematopoiesis. Immunostaining of placenta sections during development localizes hematopoietic cells in close contact with pericytes/perivascular cells. Thus, the human placenta is a potent hematopoietic niche throughout development.

AB - Hematopoietic stem cells (HSCs) are responsible for the life-long production of the blood system and are pivotal cells in hematologic transplantation therapies. During mouse and human development, the first HSCs are produced in the aorta-gonad-mesonephros region. Subsequent to this emergence, HSCs are found in other anatomical sites of the mouse conceptus. While the mouse placenta contains abundant HSCs at midgestation, little is known concerning whether HSCs or hematopoietic progenitors are present and supported in the human placenta during development. In this study we show, over a range of developmental times including term, that the human placenta contains hematopoietic progenitors and HSCs. Moreover, stromal cell lines generated from human placenta at several developmental time points are pericyte-like cells and support human hematopoiesis. Immunostaining of placenta sections during development localizes hematopoietic cells in close contact with pericytes/perivascular cells. Thus, the human placenta is a potent hematopoietic niche throughout development.

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DO - 10.1016/j.stem.2009.08.020

M3 - Article

VL - 5

SP - 385

EP - 395

JO - Cell Stem Cell

JF - Cell Stem Cell

SN - 1934-5909

IS - 4

ER -

Human Placenta Is a Potent Hematopoietic Niche Containing Hematopoietic Stem and Progenitor Cells throughout Development

Abstract

Keywords

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