TY - JOUR
T1 - Human Placenta Is a Potent Hematopoietic Niche Containing Hematopoietic Stem and Progenitor Cells throughout Development
AU - Robin, Catherine
AU - Bollerot, Karine
AU - Mendes, Sandra
AU - Haak, Esther
AU - Crisan, Mihaela
AU - Cerisoli, Francesco
AU - Lauw, Ivoune
AU - Kaimakis, Polynikis
AU - Jorna, Ruud
AU - Vermeulen, Mark
AU - Kayser, Manfred
AU - Van Der Linden, Reinier
AU - Imanirad, Parisa
AU - Verstegen, Monique
AU - Nawaz-yousaf, Humaira
AU - Papazian, Natalie
AU - Steegers, Eric
AU - Cupedo, Tom
AU - Dzierzak, Elaine
PY - 2009/10/1
Y1 - 2009/10/1
N2 - Hematopoietic stem cells (HSCs) are responsible for the life-long production of the blood system and are pivotal cells in hematologic transplantation therapies. During mouse and human development, the first HSCs are produced in the aorta-gonad-mesonephros region. Subsequent to this emergence, HSCs are found in other anatomical sites of the mouse conceptus. While the mouse placenta contains abundant HSCs at midgestation, little is known concerning whether HSCs or hematopoietic progenitors are present and supported in the human placenta during development. In this study we show, over a range of developmental times including term, that the human placenta contains hematopoietic progenitors and HSCs. Moreover, stromal cell lines generated from human placenta at several developmental time points are pericyte-like cells and support human hematopoiesis. Immunostaining of placenta sections during development localizes hematopoietic cells in close contact with pericytes/perivascular cells. Thus, the human placenta is a potent hematopoietic niche throughout development.
AB - Hematopoietic stem cells (HSCs) are responsible for the life-long production of the blood system and are pivotal cells in hematologic transplantation therapies. During mouse and human development, the first HSCs are produced in the aorta-gonad-mesonephros region. Subsequent to this emergence, HSCs are found in other anatomical sites of the mouse conceptus. While the mouse placenta contains abundant HSCs at midgestation, little is known concerning whether HSCs or hematopoietic progenitors are present and supported in the human placenta during development. In this study we show, over a range of developmental times including term, that the human placenta contains hematopoietic progenitors and HSCs. Moreover, stromal cell lines generated from human placenta at several developmental time points are pericyte-like cells and support human hematopoiesis. Immunostaining of placenta sections during development localizes hematopoietic cells in close contact with pericytes/perivascular cells. Thus, the human placenta is a potent hematopoietic niche throughout development.
KW - STEMCELL
U2 - 10.1016/j.stem.2009.08.020
DO - 10.1016/j.stem.2009.08.020
M3 - Article
VL - 5
SP - 385
EP - 395
JO - Cell Stem Cell
JF - Cell Stem Cell
SN - 1934-5909
IS - 4
ER -