Human population structure, genome autozygosity and human health

Harry Campbell, Igor Rudan, Alan H Bittles, Alan F Wright

Research output: Contribution to journalArticlepeer-review

Abstract

A major transition in human population structure is currently under way, moving from a historical metapopulation, comprising small and mainly rural endogamous communities, to large and increasingly panmictic urban populations. This process is predicted to increase outbreeding, and preliminary data from genomic surveys have helped to quantify the potential magnitude of the effects. Population genetic trends of this nature should result in a reduced burden of recessive disorders, and have a favourable impact on complex diseases influenced by partially recessive genetic variants of smaller effect. The overall outcome is expected to be beneficial for a range of traits associated with human health and disease that show dominance variance.
Original languageEnglish
Pages (from-to)91
JournalGenome Medicine
Volume1
Issue number9
DOIs
Publication statusPublished - 2009

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