Human telomeres: fusion and interstitial sites

N D Hastie, R C Allshire

Research output: Contribution to journalArticlepeer-review

Abstract

The ends of human chromosomes have been shown recently to resemble those of simple organisms. With this in mind, we discuss the nature and possible significance of rare chromosome fusion events thought to involve telomeres, particularly those fusion events found in some tumours. Also we argue that interstitial telomere-like stretches may be particularly prone to recombination, breakage and fragility.

Original languageEnglish
Pages (from-to)326-31
Number of pages6
JournalTrends in Genetics
Volume5
Issue number10
Publication statusPublished - Oct 1989

Keywords

  • Animals
  • Chromosomes, Human
  • DNA Replication
  • Humans
  • Male
  • Neoplasms
  • Recombination, Genetic
  • Repetitive Sequences, Nucleic Acid

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