Hybrid peeling for fast and accurate calling, phasing, and imputation with sequence data of any coverage in pedigrees

Andrew Whalen, Roger Ros Freixedes, David L. Wilson, Gregor Gorjanc, John Hickey

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

In this paper, we extend multi-locus iterative peeling to provide a computationally efficient method for calling, phasing, and imputing sequence data of any coverage in small or large pedigrees. Our method, called hybrid peeling, uses multi-locus iterative peeling to estimate shared chromosome segments between parents and their offspring at a subset of loci, and then uses single-locus iterative peeling to aggregate genomic information across multiple generations at the remaining loci.
Original languageEnglish
Article number67
Number of pages15
JournalGenetics Selection Evolution
Volume50
Issue number1
DOIs
Publication statusPublished - 18 Dec 2018

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