Abstract
This report discloses a novel concise synthesis of a series of 3-hydroxypyrazoles 5 via a tandem Ugi/debenzylation /hydrazine-mediated cyclization sequence. Herein, n-butyl isocyanide 4b was utilized as an alternative to classical convertible isocyanides enabling high yielding hydrazine-mediated cyclization. Taken together, a novel class of 3-hydroxypyrazoles 5a–5i was synthesized with a potential to be of interest in future library enrichment strategies.
Original language | English |
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Pages (from-to) | 2592-2594 |
Journal | Tetrahedron Letters |
Volume | 53 |
Issue number | 21 |
DOIs | |
Publication status | Published - 23 May 2012 |
Keywords / Materials (for Non-textual outputs)
- Multicomponent reaction
- Ugi reaction
- 3-Hydroxypyrazole
- Hydrazine-mediated cyclization