HYPE applied to the modelling of hybrid biological systems

Vashti Galpin; Jane Hillston; Luca Bortolussi

doi:10.1016/j.entcs.2008.10.004

HYPE applied to the modelling of hybrid biological systems

Vashti Galpin, Jane Hillston, Luca Bortolussi

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

HYPE is a process algebra developed to model hybrid systems – systems that show both continuous and discrete behaviour. It is novel because it allows for the modelling of individual flows which means that subcomponents can be modelled in terms of these flows and do not need to be described monolithically. Biological systems display discrete behaviour inherently, but modellers may choose to model systems in a hybrid fashion, often to deal with differences in scale. We demonstrate how HYPE can be used to model the Repressilator.

Original language	English
Pages (from-to)	33-51
Number of pages	19
Journal	Electronic Notes in Theoretical Computer Science
Volume	218
DOIs	https://doi.org/10.1016/j.entcs.2008.10.004
Publication status	Published - 2008

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10.1016/j.entcs.2008.10.004

hypeFinal published version, 372 KB

http://www.sciencedirect.com/science/article/pii/S1571066108003988

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title = "HYPE applied to the modelling of hybrid biological systems",

abstract = "HYPE is a process algebra developed to model hybrid systems – systems that show both continuous and discrete behaviour. It is novel because it allows for the modelling of individual flows which means that subcomponents can be modelled in terms of these flows and do not need to be described monolithically. Biological systems display discrete behaviour inherently, but modellers may choose to model systems in a hybrid fashion, often to deal with differences in scale. We demonstrate how HYPE can be used to model the Repressilator.",

author = "Vashti Galpin and Jane Hillston and Luca Bortolussi",

year = "2008",

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AU - Bortolussi, Luca

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AB - HYPE is a process algebra developed to model hybrid systems – systems that show both continuous and discrete behaviour. It is novel because it allows for the modelling of individual flows which means that subcomponents can be modelled in terms of these flows and do not need to be described monolithically. Biological systems display discrete behaviour inherently, but modellers may choose to model systems in a hybrid fashion, often to deal with differences in scale. We demonstrate how HYPE can be used to model the Repressilator.

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DO - 10.1016/j.entcs.2008.10.004

M3 - Article

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EP - 51

JO - Electronic Notes in Theoretical Computer Science

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HYPE applied to the modelling of hybrid biological systems

Abstract / Description of output

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SIGNAL: SIGNAL -Stochastic process algebra for biochemical signaling pathway analysis

SynthSys; formerly CSBE: Centre for Systems Biology at Edinburgh

CODA: Process Algebra Approaches to Collective Dynamics

Cite this

HYPE applied to the modelling of hybrid biological systems

Abstract / Description of output

Access to Document

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Projects

SIGNAL: SIGNAL -Stochastic process algebra for biochemical signaling pathway analysis

SynthSys; formerly CSBE: Centre for Systems Biology at Edinburgh

CODA: Process Algebra Approaches to Collective Dynamics

Cite this