Hyperfibrinolysis in alcoholic cirrhosis: relative plasminogen activator inhibitor type 1 deficiency

James W Ferguson, Ahmed Helmy, Christopher Ludlam, David J Webb, Peter C Hayes, David C Newby

Research output: Contribution to journalArticlepeer-review

Abstract

Over activity of the fibrinolytic system (hyperfibrinolysis) occurs in cirrhosis and has been shown to correlate with the risk of variceal hemorrhage. We have developed a model for assessing acute tissue plasminogen activator (t-PA) release in vivo in man. The aims of the study were to assess the contribution of basal and stimulated t-PA release to hyperfibrinolysis in patients with alcoholic cirrhosis.
Original languageEnglish
Pages (from-to)675-80
Number of pages6
JournalThrombosis Research: Vascular Obstruction, Hemorrhage and Hemostasis
Volume121
Issue number5
DOIs
Publication statusPublished - 2008

Keywords

  • Bradykinin
  • Female
  • Fibrinolysis
  • Humans
  • Liver Cirrhosis, Alcoholic
  • Male
  • Middle Aged
  • Nitroprusside
  • Plasminogen Activator Inhibitor 1
  • Tissue Plasminogen Activator

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