Hyperfibrinolysis in alcoholic cirrhosis: relative plasminogen activator inhibitor type 1 deficiency

James W Ferguson; Ahmed Helmy; Christopher Ludlam; David J Webb; Peter C Hayes; David C Newby

doi:10.1016/j.thromres.2007.07.008

Hyperfibrinolysis in alcoholic cirrhosis: relative plasminogen activator inhibitor type 1 deficiency

James W Ferguson
, Ahmed Helmy
, Christopher Ludlam
, David J Webb
, Peter C Hayes
, David C Newby

Research output: Contribution to journal › Article › peer-review

Abstract

Over activity of the fibrinolytic system (hyperfibrinolysis) occurs in cirrhosis and has been shown to correlate with the risk of variceal hemorrhage. We have developed a model for assessing acute tissue plasminogen activator (t-PA) release in vivo in man. The aims of the study were to assess the contribution of basal and stimulated t-PA release to hyperfibrinolysis in patients with alcoholic cirrhosis.

Original language	English
Pages (from-to)	675-80
Number of pages	6
Journal	Thrombosis Research: Vascular Obstruction, Hemorrhage and Hemostasis
Volume	121
Issue number	5
DOIs	https://doi.org/10.1016/j.thromres.2007.07.008
Publication status	Published - 2008

Keywords / Materials (for Non-textual outputs)

Bradykinin
Female
Fibrinolysis
Humans
Liver Cirrhosis, Alcoholic
Male
Middle Aged
Nitroprusside
Plasminogen Activator Inhibitor 1
Tissue Plasminogen Activator

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10.1016/j.thromres.2007.07.008

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title = "Hyperfibrinolysis in alcoholic cirrhosis: relative plasminogen activator inhibitor type 1 deficiency",

abstract = "Over activity of the fibrinolytic system (hyperfibrinolysis) occurs in cirrhosis and has been shown to correlate with the risk of variceal hemorrhage. We have developed a model for assessing acute tissue plasminogen activator (t-PA) release in vivo in man. The aims of the study were to assess the contribution of basal and stimulated t-PA release to hyperfibrinolysis in patients with alcoholic cirrhosis.",

keywords = "Bradykinin, Female, Fibrinolysis, Humans, Liver Cirrhosis, Alcoholic, Male, Middle Aged, Nitroprusside, Plasminogen Activator Inhibitor 1, Tissue Plasminogen Activator",

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doi = "10.1016/j.thromres.2007.07.008",

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T1 - Hyperfibrinolysis in alcoholic cirrhosis: relative plasminogen activator inhibitor type 1 deficiency

AU - Ferguson, James W

AU - Helmy, Ahmed

AU - Ludlam, Christopher

AU - Webb, David J

AU - Hayes, Peter C

AU - Newby, David C

PY - 2008

Y1 - 2008

N2 - Over activity of the fibrinolytic system (hyperfibrinolysis) occurs in cirrhosis and has been shown to correlate with the risk of variceal hemorrhage. We have developed a model for assessing acute tissue plasminogen activator (t-PA) release in vivo in man. The aims of the study were to assess the contribution of basal and stimulated t-PA release to hyperfibrinolysis in patients with alcoholic cirrhosis.

AB - Over activity of the fibrinolytic system (hyperfibrinolysis) occurs in cirrhosis and has been shown to correlate with the risk of variceal hemorrhage. We have developed a model for assessing acute tissue plasminogen activator (t-PA) release in vivo in man. The aims of the study were to assess the contribution of basal and stimulated t-PA release to hyperfibrinolysis in patients with alcoholic cirrhosis.

KW - Bradykinin

KW - Female

KW - Fibrinolysis

KW - Humans

KW - Liver Cirrhosis, Alcoholic

KW - Male

KW - Middle Aged

KW - Nitroprusside

KW - Plasminogen Activator Inhibitor 1

KW - Tissue Plasminogen Activator

UR - https://www.scopus.com/pages/publications/39849108394

U2 - 10.1016/j.thromres.2007.07.008

DO - 10.1016/j.thromres.2007.07.008

M3 - Article

C2 - 17870147

SN - 0049-3848

VL - 121

SP - 675

EP - 680

JO - Thrombosis Research: Vascular Obstruction, Hemorrhage and Hemostasis

JF - Thrombosis Research: Vascular Obstruction, Hemorrhage and Hemostasis

IS - 5

ER -

Hyperfibrinolysis in alcoholic cirrhosis: relative plasminogen activator inhibitor type 1 deficiency

Abstract

Keywords / Materials (for Non-textual outputs)

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