Hyperpolarization of human mesenchymal stem cells in response to magnetic force

Glen R Kirkham, Kerry J Elliot, Ahmed Keramane, Donald M Salter, Jon P Dobson, Alicia J El Haj, Sarah Harriet Cartmell

Research output: Contribution to journalArticlepeer-review

Abstract

Magnetic particle tagging techniques are currently being applied to tissue engineering applications such as controlled differentiation of mesenchymal stem cells (MSC). In order to define key mechanotransducers underpinning these applications, the electrophysiological responses of human MSCs (hMSC) have been investigated. Ferromagnetic microparticles were coated with L-arginyl-glycyl-L-aspartic acid in order to target the application of dynamic force (6 pN) directly to cell surface integrins. Human MSCs demonstrated cell membrane hyperpolarization responses after the application of force, mediated by BK channels and intracellular calcium release.
Original languageEnglish
Pages (from-to)71-4
Number of pages4
JournalIEEE transactions on nanobioscience
Volume9
Issue number1
DOIs
Publication statusPublished - Mar 2010

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