Hyperpolarized (3)helium gas for functional magnetic resonance imaging of the lung

Claus Peter Heussel, Klaus K Gast, Anja Dahmen, Andreas E Morbach, Hans-Ulrich Kauczor, Wolfgang G Schreiber, Manfred Thelen, Edwin J R van Beek

Research output: Contribution to journalArticlepeer-review


Lung imaging is traditionally done using X-ray-based methods, since MRI is limited by low proton density as well as inherent magnetic field inhomogeneities of the lung tissue. After introduction of MRI using hyperpolarized noble gases, a totally new field of MRI of the chest has rapidly evolved. These techniques reveal new functional information of the lungs, which could not be obtained before. The first part of this review describes the underlying MR technology explaining distribution of static ventilation, dynamic distribution of ventilation, lung microstructure (apparent diffusion coefficient [ADC]), measurement of oxygen partial pressure (pO(2)), and safety. The clinical potential is afterwards demonstrated in the second part. Therefore, the effort in normal lungs and the mainly focused diseases chronic obstructive pulmonary disease (COPD), smoker's lung, cystic fibrosis, asthma, lung transplantation, and pulmonary embolism are reported.

Translated title of the contributionHyperpolarized (3)helium gas for functional magnetic resonance imaging of the lung
Original languageGerman
Pages (from-to)413-24
Number of pages12
JournalMedizinische Klinik
Issue number7
Publication statusPublished - 15 Jul 2005


  • Administration, Inhalation
  • Contrast Media
  • Helium
  • Humans
  • Image Enhancement
  • Image Processing, Computer-Assisted
  • Isotopes
  • Lung Diseases
  • Magnetic Resonance Imaging
  • Oxygen
  • Pulmonary Diffusing Capacity
  • Pulmonary Disease, Chronic Obstructive
  • Pulmonary Gas Exchange
  • Reference Values
  • Sensitivity and Specificity
  • Smoking
  • Ventilation-Perfusion Ratio


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