Hypersensitivity pneumonitis associated with co-proxamol (paracetamol + dextropropoxyphene) therapy

S P Matusiewicz, W A Wallace, G K Crompton

Research output: Contribution to journalArticlepeer-review


A 61-year-old man developed hypersensitivity pneumonitis and skin rash in close association with taking co-proxamol. These problems occurred in spite of being treated with prednisolone 40 mg daily (20 mg daily at the time of presentation) for assumed cranial arteritis. A therapeutic challenge with paracetamol was negative and the patient continues to take this drug. It seems likely that this patient's rash and hypersensitivity pneumonitis was caused by dextropropoxyphene. Dextropropoxyphene has not been reported previously as a cause of hypersensitivity pneumonitis.

Original languageEnglish
Pages (from-to)475-6
Number of pages2
JournalPostgraduate Medical Journal
Issue number886
Publication statusPublished - Aug 1999


  • Acetaminophen
  • Alveolitis, Extrinsic Allergic
  • Analgesics
  • Anti-Inflammatory Agents
  • Dextropropoxyphene
  • Drug Combinations
  • Drug Eruptions
  • Giant Cell Arteritis
  • Humans
  • Male
  • Middle Aged
  • Prednisolone


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