Hypertension fails to disrupt white matter integrity in young or aged Fisher (F44) Cyp1a1Ren2 transgenic rats

Philip R Holland; Mercede A Pannozzo; Mark E Bastin; Allison D McNeilly; Karen J Ferguson; Sarah Caughey; Maurits A Jansen; Gavin D Merrifield; Ian Marshall; John J Mullins; Joanna M Wardlaw; Calum Sutherland; Karen Horsburgh

doi:10.1038/jcbfm.2014.201

Hypertension fails to disrupt white matter integrity in young or aged Fisher (F44) Cyp1a1Ren2 transgenic rats

Philip R Holland, Mercede A Pannozzo, Mark E Bastin, Allison D McNeilly, Karen J Ferguson, Sarah Caughey, Maurits A Jansen, Gavin D Merrifield, Ian Marshall, John J Mullins, Joanna M Wardlaw, Calum Sutherland, Karen Horsburgh

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Abstract / Description of output

Hypertension is linked with an increased risk of white matter hyperintensities; however, recent findings have questioned this association. We examined whether hypertension and additional cerebrovascular risk factors impacted on white matter integrity in an inducible hypertensive rat. No white matter hyperintensities were observed on magnetic resonance imaging either alone or in conjunction with ageing and high-fat diet. Aged hypertensive rats that were fed a high-fat diet had moderately reduced fractional anisotropy in the corpus callosum with no overt pathological features. Herein we show that moderate hypertension alone or with additional risk factors has minimal impact on white matter integrity in this model.Journal of Cerebral Blood Flow & Metabolism advance online publication, 19 November 2014; doi:10.1038/jcbfm.2014.201.

Original language	English
Pages (from-to)	188-192
Journal	Journal of Cerebral Blood Flow and Metabolism
Volume	35
Early online date	19 Nov 2014
DOIs	https://doi.org/10.1038/jcbfm.2014.201
Publication status	Published - Feb 2015

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Holland, P. R., Pannozzo, M. A., Bastin, M. E., McNeilly, A. D., Ferguson, K. J., Caughey, S., Jansen, M. A., Merrifield, G. D., Marshall, I., Mullins, J. J., Wardlaw, J. M., Sutherland, C., & Horsburgh, K. (2015). Hypertension fails to disrupt white matter integrity in young or aged Fisher (F44) Cyp1a1Ren2 transgenic rats. Journal of Cerebral Blood Flow and Metabolism, 35, 188-192. https://doi.org/10.1038/jcbfm.2014.201

@article{41baa4e3900f438aa62e805c2b615e77,

title = "Hypertension fails to disrupt white matter integrity in young or aged Fisher (F44) Cyp1a1Ren2 transgenic rats",

abstract = "Hypertension is linked with an increased risk of white matter hyperintensities; however, recent findings have questioned this association. We examined whether hypertension and additional cerebrovascular risk factors impacted on white matter integrity in an inducible hypertensive rat. No white matter hyperintensities were observed on magnetic resonance imaging either alone or in conjunction with ageing and high-fat diet. Aged hypertensive rats that were fed a high-fat diet had moderately reduced fractional anisotropy in the corpus callosum with no overt pathological features. Herein we show that moderate hypertension alone or with additional risk factors has minimal impact on white matter integrity in this model.Journal of Cerebral Blood Flow & Metabolism advance online publication, 19 November 2014; doi:10.1038/jcbfm.2014.201.",

author = "Holland, {Philip R} and Pannozzo, {Mercede A} and Bastin, {Mark E} and McNeilly, {Allison D} and Ferguson, {Karen J} and Sarah Caughey and Jansen, {Maurits A} and Merrifield, {Gavin D} and Ian Marshall and Mullins, {John J} and Wardlaw, {Joanna M} and Calum Sutherland and Karen Horsburgh",

year = "2015",

month = feb,

doi = "10.1038/jcbfm.2014.201",

language = "English",

volume = "35",

pages = "188--192",

journal = "Journal of Cerebral Blood Flow and Metabolism",

issn = "1559-7016",

publisher = "LIPPINCOTT-RAVEN PUBL",

}

Holland, PR, Pannozzo, MA, Bastin, ME, McNeilly, AD, Ferguson, KJ , Caughey, S, Jansen, MA, Merrifield, GD, Marshall, I, Mullins, JJ, Wardlaw, JM, Sutherland, C & Horsburgh, K 2015, 'Hypertension fails to disrupt white matter integrity in young or aged Fisher (F44) Cyp1a1Ren2 transgenic rats', Journal of Cerebral Blood Flow and Metabolism, vol. 35, pp. 188-192. https://doi.org/10.1038/jcbfm.2014.201

TY - JOUR

T1 - Hypertension fails to disrupt white matter integrity in young or aged Fisher (F44) Cyp1a1Ren2 transgenic rats

AU - Holland, Philip R

AU - Pannozzo, Mercede A

AU - Bastin, Mark E

AU - McNeilly, Allison D

AU - Ferguson, Karen J

AU - Caughey, Sarah

AU - Jansen, Maurits A

AU - Merrifield, Gavin D

AU - Marshall, Ian

AU - Mullins, John J

AU - Wardlaw, Joanna M

AU - Sutherland, Calum

AU - Horsburgh, Karen

PY - 2015/2

Y1 - 2015/2

N2 - Hypertension is linked with an increased risk of white matter hyperintensities; however, recent findings have questioned this association. We examined whether hypertension and additional cerebrovascular risk factors impacted on white matter integrity in an inducible hypertensive rat. No white matter hyperintensities were observed on magnetic resonance imaging either alone or in conjunction with ageing and high-fat diet. Aged hypertensive rats that were fed a high-fat diet had moderately reduced fractional anisotropy in the corpus callosum with no overt pathological features. Herein we show that moderate hypertension alone or with additional risk factors has minimal impact on white matter integrity in this model.Journal of Cerebral Blood Flow & Metabolism advance online publication, 19 November 2014; doi:10.1038/jcbfm.2014.201.

AB - Hypertension is linked with an increased risk of white matter hyperintensities; however, recent findings have questioned this association. We examined whether hypertension and additional cerebrovascular risk factors impacted on white matter integrity in an inducible hypertensive rat. No white matter hyperintensities were observed on magnetic resonance imaging either alone or in conjunction with ageing and high-fat diet. Aged hypertensive rats that were fed a high-fat diet had moderately reduced fractional anisotropy in the corpus callosum with no overt pathological features. Herein we show that moderate hypertension alone or with additional risk factors has minimal impact on white matter integrity in this model.Journal of Cerebral Blood Flow & Metabolism advance online publication, 19 November 2014; doi:10.1038/jcbfm.2014.201.

U2 - 10.1038/jcbfm.2014.201

DO - 10.1038/jcbfm.2014.201

M3 - Article

C2 - 25407269

SN - 1559-7016

VL - 35

SP - 188

EP - 192

JO - Journal of Cerebral Blood Flow and Metabolism

JF - Journal of Cerebral Blood Flow and Metabolism

ER -

Hypertension fails to disrupt white matter integrity in young or aged Fisher (F44) Cyp1a1Ren2 transgenic rats

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