Methods: A total of 12 PD patients and 12 matched controls underwent magnetic resonance imaging to determine hypothalamic volume. In addition, PD patients underwent 24‐hour blood sampling in a controlled environment to determine serum melatonin concentrations using enzyme‐linked immunosorbent assays.
Results: PD patients had significantly reduced hypothalamic gray matter volume when compared with matched controls. Melatonin levels were significantly associated with hypothalamic gray matter volume and disease severity in PD patients.
Conclusion: Melatonin levels are associated with hypothalamic gray matter volume loss and disease severity in PD patients. This provides anatomical and physiological support for an intrinsic sleep and circadian phenotype in PD. © 2016 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society
- Centre for Clinical Brain Sciences - Senior Clinical Research Fellow
- Anne Rowling Regenerative Neurology Clinic - Senior Clinical Research Fellow
- Edinburgh Neuroscience
- Deanery of Clinical Sciences - Senior Clinical Research Fellow
- Usher Institute - Senior Clinical Research Fellow
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