Hypoxanthine Phosphoribosyltransferase (HPRT)-deficiency is associated with impaired fertility in the female rat

Stephen Meek; Linda Sutherland; Jun Wei; Roger  Sturmey; Bert  Binas; Mike Clinton; Tom Burdon

doi:10.1002/mrd.23413

Hypoxanthine Phosphoribosyltransferase (HPRT)-deficiency is associated with impaired fertility in the female rat

Stephen Meek, Linda Sutherland, Jun Wei, Roger Sturmey, Bert Binas, Mike Clinton, Tom Burdon

Royal (Dick) School of Veterinary Studies

Research output: Contribution to journal › Article › peer-review

Abstract

The purine hypoxanthine plays important role in regulating oocyte maturation and early embryonic development. The enzyme hypoxanthine phosphoribosyltransferase (HPRT) recycles hypoxanthine to generate substrates for nucleotide synthesis and key metabolites, and here we show that HPRT deficiency in the rat disrupts early embryonic development and causes infertility in females ...

Original language	English
Journal	Molecular Reproduction and Development
Early online date	27 Aug 2020
DOIs	https://doi.org/10.1002/mrd.23413
Publication status	E-pub ahead of print - 27 Aug 2020

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10.1002/mrd.23413

Mrd
© 2020 The Authors. Molecular Reproduction and Development published by Wiley Periodicals LLC This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Final published version, 2.43 MBLicence: Creative Commons: Attribution (CC-BY)

Tom Burdon
- tom.burdonroslin.ed.acuk
- Royal (Dick) School of Veterinary Studies - Group Leader/Senior Research Fellow
Person: Academic: Research Active

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title = "Hypoxanthine Phosphoribosyltransferase (HPRT)-deficiency is associated with impaired fertility in the female rat",

abstract = "The purine hypoxanthine plays important role in regulating oocyte maturation and early embryonic development. The enzyme hypoxanthine phosphoribosyltransferase (HPRT) recycles hypoxanthine to generate substrates for nucleotide synthesis and key metabolites, and here we show that HPRT deficiency in the rat disrupts early embryonic development and causes infertility in females ...",

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AU - Meek, Stephen

AU - Sutherland, Linda

AU - Wei, Jun

AU - Sturmey, Roger

AU - Binas, Bert

AU - Clinton, Mike

AU - Burdon, Tom

PY - 2020/8/27

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AB - The purine hypoxanthine plays important role in regulating oocyte maturation and early embryonic development. The enzyme hypoxanthine phosphoribosyltransferase (HPRT) recycles hypoxanthine to generate substrates for nucleotide synthesis and key metabolites, and here we show that HPRT deficiency in the rat disrupts early embryonic development and causes infertility in females ...

U2 - 10.1002/mrd.23413

DO - 10.1002/mrd.23413

M3 - Article

JO - Molecular Reproduction and Development

JF - Molecular Reproduction and Development

SN - 1040-425X

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Hypoxanthine Phosphoribosyltransferase (HPRT)-deficiency is associated with impaired fertility in the female rat

Abstract

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Tom Burdon

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