Abstract
The purine hypoxanthine plays important role in regulating oocyte maturation and early embryonic development. The enzyme hypoxanthine phosphoribosyltransferase (HPRT) recycles hypoxanthine to generate substrates for nucleotide synthesis and key metabolites, and here we show that HPRT deficiency in the rat disrupts early embryonic development and causes infertility in females ...
Original language | English |
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Journal | Molecular Reproduction and Development |
Early online date | 27 Aug 2020 |
DOIs | |
Publication status | E-pub ahead of print - 27 Aug 2020 |
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Dive into the research topics of 'Hypoxanthine Phosphoribosyltransferase (HPRT)-deficiency is associated with impaired fertility in the female rat'. Together they form a unique fingerprint.Profiles
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Tom Burdon
- Royal (Dick) School of Veterinary Studies - Group Leader/Senior Research Fellow
Person: Academic: Research Active