Hypoxanthine Phosphoribosyltransferase (HPRT)-deficiency is associated with impaired fertility in the female rat

Stephen Meek, Linda Sutherland, Jun Wei, Roger Sturmey, Bert Binas, Mike Clinton, Tom Burdon

Research output: Contribution to journalArticlepeer-review

Abstract

The purine hypoxanthine plays important role in regulating oocyte maturation and early embryonic development. The enzyme hypoxanthine phosphoribosyltransferase (HPRT) recycles hypoxanthine to generate substrates for nucleotide synthesis and key metabolites, and here we show that HPRT deficiency in the rat disrupts early embryonic development and causes infertility in females ...

Original languageEnglish
JournalMolecular Reproduction and Development
Early online date27 Aug 2020
DOIs
Publication statusE-pub ahead of print - 27 Aug 2020

Fingerprint

Dive into the research topics of 'Hypoxanthine Phosphoribosyltransferase (HPRT)-deficiency is associated with impaired fertility in the female rat'. Together they form a unique fingerprint.

Cite this