Hypoxia induces dilated cardiomyopathy in the chick embryo: mechanism, intervention, and long-term consequences

Andrei Tintu; Ellen Rouwet; Stefan Verlohren; Joep Brinkmann; Shakil Ahmad; Fatima Crispi; Marc van Bilsen; Peter Carmeliet; Anne Cathrine Staff; Marc Tjwa; Irene Cetin; Eduard Gratacos; Edgar Hernandez-Andrade; Leo Hofstra; Michael Jacobs; Wouter H Lamers; Ingo Morano; Erdal Safak; Asif Ahmed; Ferdinand le Noble

doi:10.1371/journal.pone.0005155

Hypoxia induces dilated cardiomyopathy in the chick embryo: mechanism, intervention, and long-term consequences

Andrei Tintu, Ellen Rouwet, Stefan Verlohren, Joep Brinkmann, Shakil Ahmad, Fatima Crispi, Marc van Bilsen, Peter Carmeliet, Anne Cathrine Staff, Marc Tjwa, Irene Cetin, Eduard Gratacos, Edgar Hernandez-Andrade, Leo Hofstra, Michael Jacobs, Wouter H Lamers, Ingo Morano, Erdal Safak, Asif Ahmed, Ferdinand le Noble

Deanery of Clinical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Intrauterine growth restriction is associated with an increased future risk for developing cardiovascular diseases. Hypoxia in utero is a common clinical cause of fetal growth restriction. We have previously shown that chronic hypoxia alters cardiovascular development in chick embryos. The aim of this study was to further characterize cardiac disease in hypoxic chick embryos.

Original language	English
Pages (from-to)	e5155
Journal	PLoS ONE
Volume	4
Issue number	4
DOIs	https://doi.org/10.1371/journal.pone.0005155
Publication status	Published - 2009

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10.1371/journal.pone.0005155

Hypoxia induces dilated cardiomyopathy in the chick embryo
Copyright: © 2009 Tintu et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0005155

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Tintu, A., Rouwet, E., Verlohren, S., Brinkmann, J., Ahmad, S., Crispi, F., van Bilsen, M., Carmeliet, P., Staff, A. C., Tjwa, M., Cetin, I., Gratacos, E., Hernandez-Andrade, E., Hofstra, L., Jacobs, M., Lamers, W. H., Morano, I., Safak, E., Ahmed, A., & le Noble, F. (2009). Hypoxia induces dilated cardiomyopathy in the chick embryo: mechanism, intervention, and long-term consequences. PLoS ONE, 4(4), e5155. https://doi.org/10.1371/journal.pone.0005155

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abstract = "Intrauterine growth restriction is associated with an increased future risk for developing cardiovascular diseases. Hypoxia in utero is a common clinical cause of fetal growth restriction. We have previously shown that chronic hypoxia alters cardiovascular development in chick embryos. The aim of this study was to further characterize cardiac disease in hypoxic chick embryos.",

author = "Andrei Tintu and Ellen Rouwet and Stefan Verlohren and Joep Brinkmann and Shakil Ahmad and Fatima Crispi and {van Bilsen}, Marc and Peter Carmeliet and Staff, {Anne Cathrine} and Marc Tjwa and Irene Cetin and Eduard Gratacos and Edgar Hernandez-Andrade and Leo Hofstra and Michael Jacobs and Lamers, {Wouter H} and Ingo Morano and Erdal Safak and Asif Ahmed and {le Noble}, Ferdinand",

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Tintu, A, Rouwet, E, Verlohren, S, Brinkmann, J, Ahmad, S, Crispi, F, van Bilsen, M, Carmeliet, P, Staff, AC, Tjwa, M, Cetin, I, Gratacos, E, Hernandez-Andrade, E, Hofstra, L, Jacobs, M, Lamers, WH, Morano, I, Safak, E, Ahmed, A & le Noble, F 2009, 'Hypoxia induces dilated cardiomyopathy in the chick embryo: mechanism, intervention, and long-term consequences', PLoS ONE, vol. 4, no. 4, pp. e5155. https://doi.org/10.1371/journal.pone.0005155

TY - JOUR

T1 - Hypoxia induces dilated cardiomyopathy in the chick embryo

T2 - mechanism, intervention, and long-term consequences

AU - Tintu, Andrei

AU - Rouwet, Ellen

AU - Verlohren, Stefan

AU - Brinkmann, Joep

AU - Ahmad, Shakil

AU - Crispi, Fatima

AU - van Bilsen, Marc

AU - Carmeliet, Peter

AU - Staff, Anne Cathrine

AU - Tjwa, Marc

AU - Cetin, Irene

AU - Gratacos, Eduard

AU - Hernandez-Andrade, Edgar

AU - Hofstra, Leo

AU - Jacobs, Michael

AU - Lamers, Wouter H

AU - Morano, Ingo

AU - Safak, Erdal

AU - Ahmed, Asif

AU - le Noble, Ferdinand

PY - 2009

Y1 - 2009

N2 - Intrauterine growth restriction is associated with an increased future risk for developing cardiovascular diseases. Hypoxia in utero is a common clinical cause of fetal growth restriction. We have previously shown that chronic hypoxia alters cardiovascular development in chick embryos. The aim of this study was to further characterize cardiac disease in hypoxic chick embryos.

AB - Intrauterine growth restriction is associated with an increased future risk for developing cardiovascular diseases. Hypoxia in utero is a common clinical cause of fetal growth restriction. We have previously shown that chronic hypoxia alters cardiovascular development in chick embryos. The aim of this study was to further characterize cardiac disease in hypoxic chick embryos.

U2 - 10.1371/journal.pone.0005155

DO - 10.1371/journal.pone.0005155

M3 - Article

C2 - 19357774

SN - 1932-6203

VL - 4

SP - e5155

JO - PLoS ONE

JF - PLoS ONE

IS - 4

ER -

Hypoxia induces dilated cardiomyopathy in the chick embryo: mechanism, intervention, and long-term consequences

Abstract

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