Hypoxia induces histone clipping and H3K4me3 loss in neutrophil progenitors resulting in long-term impairment of neutrophil immunity

Manuel A Sanchez-Garcia, Pranvera Sadiku, Brian M Ortmann, Niek Wit, Yutaka Negishi, Patricia Coelho, Ailiang Zhang, Chinmayi Pednekar, Andrew J M Howden, David M Griffith, Rachel Seear, Jessica D Kindrick, Janine Mengede, George Cooper, Tyler Morrison, Emily R Watts, Benjamin T Shimeld, Leila Reyes, Ananda S Mirchandani, Simone ArientiXiang Xu, Alexander Thomson, Alejandro J Brenes, Helena A Turton, Rebecca Dowey, Rebecca C Hull, Hazel Davidson-Smith, Amy McLaren, Andrew Deans, Gourab Choudhury, Katherine Doverman, David Hope, Oliver Vick, Alastair Woodhead, Isla Petrie, Suzanne Green, Nina M Rzechorzek, Lance Turtle, Peter J M Openshaw, Malcolm G Semple, PHOSP‐COVID Study Collaborative Group, Duncan Sproul, J Kenneth Baillie, Alfred A R Thompson, David R Mole, Alex von Kriegsheim, Moira K B Whyte, Musa M Mhalanga, James A Nathan, Sarah R Walmsley^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

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Defining the interplay between hypoxia and metabolic adaptations of the innate immune response.
Walmsley, S. (Principal Investigator)
Wellcome Trust (Rcl)
1/01/18 → 30/06/23
Project: Research
Neurophil Functional Plasticity in Glioblastoma: A therapeutic target?
Walmsley, S. (Principal Investigator) & Whyte, M. (Co-investigator)
UK-based charities
1/07/17 → 31/08/21
Project: Research
The impact of genetic interactions on DNA methylation in breast cancer
Sproul, D. (Principal Investigator)
Cancer Research UK
1/09/16 → 31/08/23
Project: Research
Transfer from Sheffield: Regulation or neutrophilic inflammation by the HIF/PHD pathway
Walmsley, S. (Principal Investigator)
UK-based charities
1/09/14 → 31/12/17
Project: Research

Hypoxia induces histone clipping and H3K4me3 loss in neutrophil progenitors resulting in long-term impairment of neutrophil immunity

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Defining the interplay between hypoxia and metabolic adaptations of the innate immune response.

Neurophil Functional Plasticity in Glioblastoma: A therapeutic target?

The impact of genetic interactions on DNA methylation in breast cancer

Transfer from Sheffield: Regulation or neutrophilic inflammation by the HIF/PHD pathway