TY - UNPB
T1 - Hypoxia shapes the immune landscape in lung injury promoting inflammation persistence
AU - Mirchandani, Ananda S.
AU - Jenkins, Stephen J.
AU - Bain, Calum C.
AU - Lawson, Hannah
AU - Coelho, Patricia
AU - Murphy, Fiona
AU - Griffith, David
AU - Zhang, Ailiang
AU - Sanchez-Garcia, Manuel A.
AU - Reyes, Leila
AU - Morrison, Tyler
AU - Arienti, Simone
AU - Sadiku, Pranvera
AU - Watts, Emily R.
AU - Dickinson, Rebecca S.
AU - Clark, Sarah
AU - Ly, Tony
AU - Lewis, David
AU - Kelly, Van
AU - Spanos, Christos
AU - Musgrave, Kathryn M.
AU - Delaney, Liam
AU - Harper, Isla
AU - Scott, Jonathan
AU - Parkinson, Nicholas J.
AU - Rostron, Anthony J.
AU - Baillie, Kenneth J
AU - Clohisey, Sara
AU - Pridans, Clare
AU - Campana, Lara
AU - Starkey-Lewis, Philip
AU - Simpson, A John
AU - Dockrell, David
AU - Schwarze, Jurgen
AU - Hirani, Nikhil
AU - Ratcliffe, Peter J.
AU - Pugh, Christopher W.
AU - Kranc, Kamil
AU - Forbes, Stuart J.
AU - Whyte, Moira K.
AU - Walmsley, Sarah R.
PY - 2022/3/12
Y1 - 2022/3/12
N2 - Acute Respiratory Distress Syndrome (ARDS), an often-fatal complication of pulmonary or systemic inflammation, has no cure. Hypoxemia is a defining feature, yet its impact on inflammation is often neglected. Patients with ARDS are monocytopenic early in the onset of the disease. Endotoxin or Streptococcus pneumoniae acute lung injury (ALI) in the context of hypoxia replicates this finding, through hypoxia-driven suppression of type I interferon signalling. This results in failed lung monocyte-derived interstitial macrophages (IM) niche expansion and unchecked neutrophilic inflammation. Administration of colony stimulating factor 1 (CSF1) rescues the monocytopenia, alters the circulating classical monocyte phenotype in hypoxic endotoxin-driven ALI and enables lung IM population expansion, thus limiting lung injury in endotoxin- and virally-induced hypoxic ALI. Hypoxia directly alters immune dynamics to the detriment of the host and manipulation of this aberrant response offers new therapeutic strategies for ARDS.
AB - Acute Respiratory Distress Syndrome (ARDS), an often-fatal complication of pulmonary or systemic inflammation, has no cure. Hypoxemia is a defining feature, yet its impact on inflammation is often neglected. Patients with ARDS are monocytopenic early in the onset of the disease. Endotoxin or Streptococcus pneumoniae acute lung injury (ALI) in the context of hypoxia replicates this finding, through hypoxia-driven suppression of type I interferon signalling. This results in failed lung monocyte-derived interstitial macrophages (IM) niche expansion and unchecked neutrophilic inflammation. Administration of colony stimulating factor 1 (CSF1) rescues the monocytopenia, alters the circulating classical monocyte phenotype in hypoxic endotoxin-driven ALI and enables lung IM population expansion, thus limiting lung injury in endotoxin- and virally-induced hypoxic ALI. Hypoxia directly alters immune dynamics to the detriment of the host and manipulation of this aberrant response offers new therapeutic strategies for ARDS.
UR - https://doi.org/10.1101/2022.03.11.483935
U2 - 10.1101/2022.03.11.483935
DO - 10.1101/2022.03.11.483935
M3 - Preprint
SP - 1
EP - 53
BT - Hypoxia shapes the immune landscape in lung injury promoting inflammation persistence
PB - bioRxiv
ER -