IAPs: a central element in the NF-κB activating signaling pathway

Jessy Cartier, Arthur Marivin, Jean Berthelet, Laurence Dubrez

Research output: Contribution to journalLiterature reviewpeer-review

Abstract

The function of IAP has long been limited to an inhibition of apoptosis through their capacity to bind some caspases. Since the expression of these proteins is altered in some tumor samples, IAPs are targets for anticancer therapy and many small molecules have been designed for their capacity to inhibit IAP-caspase interaction. Unexpectedly, these molecules appeared to significantly affect NF-κB activation. In this review, we will discuss the central role of cIAP1, cIAP2 and XIAP in the regulation of NF-κB activating signaling pathways.

Translated title of the contributionIAPs: a central element in the NF-κB activating signaling pathway
Original languageFrench
Pages (from-to)69-75
Number of pages7
Journalmédecine/sciences
Volume28
Issue number1
DOIs
Publication statusPublished - Jan 2012

Keywords

  • Animals
  • Antineoplastic Agents
  • Bone Morphogenetic Proteins
  • DNA Damage
  • Drosophila Proteins
  • Gene Expression Regulation
  • Humans
  • Immunity, Innate
  • Inhibitor of Apoptosis Proteins
  • Mammals
  • Models, Genetic
  • Molecular Targeted Therapy
  • Multigene Family
  • NF-kappa B
  • Neoplasm Proteins
  • Protein Structure, Tertiary
  • Receptors, Tumor Necrosis Factor
  • Signal Transduction
  • Structure-Activity Relationship
  • Transcription, Genetic
  • Transforming Growth Factor beta
  • Viral Proteins
  • X-Linked Inhibitor of Apoptosis Protein

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