De novo formation and epigenetic maintenance of centromere chromatin

Junichirou Ohzeki; Vladimir Larionov; William C. Earnshaw; Hiroshi Masumoto

doi:10.1016/j.ceb.2018.12.004

De novo formation and epigenetic maintenance of centromere chromatin

Junichirou Ohzeki, Vladimir Larionov, William C. Earnshaw, Hiroshi Masumoto

School of Biological Sciences

Research output: Contribution to journal › Review article › peer-review

Abstract / Description of output

Accurate chromosome segregation is essential for cell proliferation. The centromere is a specialized chromosomal locus, on which the kinetochore structure is formed. The centromere/kinetochore is required for the equal separation of sister chromatids to daughter cells. Here, we review recent findings on centromere-specific chromatin, including its constitutive protein components, its de novo formation and maintenance mechanisms, and our progress in analyses with synthetic human artificial chromosomes (HACs).

Original language	English
Pages (from-to)	15-25
Number of pages	11
Journal	Current opinion in cell biology
Volume	58
Early online date	15 Jan 2019
DOIs	https://doi.org/10.1016/j.ceb.2018.12.004
Publication status	Published - 1 Jun 2019

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10.1016/j.ceb.2018.12.004

1-s2.0-S0955067418301650-mainFinal published version, 2.75 MBLicence: CC BY-NC-ND

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title = "De novo formation and epigenetic maintenance of centromere chromatin",

abstract = "Accurate chromosome segregation is essential for cell proliferation. The centromere is a specialized chromosomal locus, on which the kinetochore structure is formed. The centromere/kinetochore is required for the equal separation of sister chromatids to daughter cells. Here, we review recent findings on centromere-specific chromatin, including its constitutive protein components, its de novo formation and maintenance mechanisms, and our progress in analyses with synthetic human artificial chromosomes (HACs).",

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AU - Ohzeki, Junichirou

AU - Larionov, Vladimir

AU - Earnshaw, William C.

AU - Masumoto, Hiroshi

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Y1 - 2019/6/1

N2 - Accurate chromosome segregation is essential for cell proliferation. The centromere is a specialized chromosomal locus, on which the kinetochore structure is formed. The centromere/kinetochore is required for the equal separation of sister chromatids to daughter cells. Here, we review recent findings on centromere-specific chromatin, including its constitutive protein components, its de novo formation and maintenance mechanisms, and our progress in analyses with synthetic human artificial chromosomes (HACs).

AB - Accurate chromosome segregation is essential for cell proliferation. The centromere is a specialized chromosomal locus, on which the kinetochore structure is formed. The centromere/kinetochore is required for the equal separation of sister chromatids to daughter cells. Here, we review recent findings on centromere-specific chromatin, including its constitutive protein components, its de novo formation and maintenance mechanisms, and our progress in analyses with synthetic human artificial chromosomes (HACs).

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De novo formation and epigenetic maintenance of centromere chromatin

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The role of non-histone proteins in chromosome structure and function during mitosis

The role of non-histone proteins in chromosome structure and function during mitosis and apoptosis

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De novo formation and epigenetic maintenance of centromere chromatin

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The role of non-histone proteins in chromosome structure and function during mitosis

The role of non-histone proteins in chromosome structure and function during mitosis and apoptosis

Cite this