Identification and survival of carriers of mutations in DNA mismatch-repair genes in colon cancer

Rebecca A Barnetson, Albert Tenesa, Susan M Farrington, Iain D Nicholl, Roseanne Cetnarskyj, Mary E Porteous, Harry Campbell, Malcolm G Dunlop

Research output: Contribution to journalArticlepeer-review

Abstract

The identification of mutations in germ-line DNA mismatch-repair genes at the time of diagnosis of colorectal cancer is important in the management of the disease.
Original languageEnglish
Pages (from-to)2751-63
Number of pages13
JournalNew England Journal of Medicine
Volume354
Issue number26
DOIs
Publication statusPublished - 29 Jun 2006

Keywords

  • Adaptor Proteins, Signal Transducing
  • Adult
  • Analysis of Variance
  • Base Pair Mismatch
  • Carrier Proteins
  • Colorectal Neoplasms, Hereditary Nonpolyposis
  • DNA Mutational Analysis
  • DNA Repair
  • DNA-Binding Proteins
  • Female
  • Genotype
  • Germ-Line Mutation
  • Heterozygote
  • Humans
  • Immunohistochemistry
  • Logistic Models
  • Male
  • Microsatellite Repeats
  • Middle Aged
  • MutS Homolog 2 Protein
  • Nuclear Proteins
  • Prognosis
  • Prospective Studies
  • Survival Analysis

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