Identification and survival of carriers of mutations in DNA mismatch-repair genes in colon cancer

Rebecca A Barnetson; Albert Tenesa; Susan M Farrington; Iain D Nicholl; Roseanne Cetnarskyj; Mary E Porteous; Harry Campbell; Malcolm G Dunlop

doi:10.1056/NEJMoa053493

Identification and survival of carriers of mutations in DNA mismatch-repair genes in colon cancer

Rebecca A Barnetson, Albert Tenesa, Susan M Farrington, Iain D Nicholl, Roseanne Cetnarskyj, Mary E Porteous, Harry Campbell, Malcolm G Dunlop

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

The identification of mutations in germ-line DNA mismatch-repair genes at the time of diagnosis of colorectal cancer is important in the management of the disease.

Original language	English
Pages (from-to)	2751-63
Number of pages	13
Journal	New England Journal of Medicine
Volume	354
Issue number	26
DOIs	https://doi.org/10.1056/NEJMoa053493
Publication status	Published - 29 Jun 2006

Keywords / Materials (for Non-textual outputs)

Adaptor Proteins, Signal Transducing
Adult
Analysis of Variance
Base Pair Mismatch
Carrier Proteins
Colorectal Neoplasms, Hereditary Nonpolyposis
DNA Mutational Analysis
DNA Repair
DNA-Binding Proteins
Female
Genotype
Germ-Line Mutation
Heterozygote
Humans
Immunohistochemistry
Logistic Models
Male
Microsatellite Repeats
Middle Aged
MutS Homolog 2 Protein
Nuclear Proteins
Prognosis
Prospective Studies
Survival Analysis

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10.1056/NEJMoa053493

Cite this

@article{e07ba1c5b47d4adc9924b1805cbb2af6,

title = "Identification and survival of carriers of mutations in DNA mismatch-repair genes in colon cancer",

abstract = "The identification of mutations in germ-line DNA mismatch-repair genes at the time of diagnosis of colorectal cancer is important in the management of the disease.",

keywords = "Adaptor Proteins, Signal Transducing, Adult, Analysis of Variance, Base Pair Mismatch, Carrier Proteins, Colorectal Neoplasms, Hereditary Nonpolyposis, DNA Mutational Analysis, DNA Repair, DNA-Binding Proteins, Female, Genotype, Germ-Line Mutation, Heterozygote, Humans, Immunohistochemistry, Logistic Models, Male, Microsatellite Repeats, Middle Aged, MutS Homolog 2 Protein, Nuclear Proteins, Prognosis, Prospective Studies, Survival Analysis",

author = "Barnetson, {Rebecca A} and Albert Tenesa and Farrington, {Susan M} and Nicholl, {Iain D} and Roseanne Cetnarskyj and Porteous, {Mary E} and Harry Campbell and Dunlop, {Malcolm G}",

year = "2006",

month = jun,

day = "29",

doi = "10.1056/NEJMoa053493",

language = "English",

volume = "354",

pages = "2751--63",

journal = "New England Journal of Medicine",

issn = "0028-4793",

publisher = "MASSACHUSETTS MEDICAL SOC",

number = "26",

}

TY - JOUR

T1 - Identification and survival of carriers of mutations in DNA mismatch-repair genes in colon cancer

AU - Barnetson, Rebecca A

AU - Tenesa, Albert

AU - Farrington, Susan M

AU - Nicholl, Iain D

AU - Cetnarskyj, Roseanne

AU - Porteous, Mary E

AU - Campbell, Harry

AU - Dunlop, Malcolm G

PY - 2006/6/29

Y1 - 2006/6/29

N2 - The identification of mutations in germ-line DNA mismatch-repair genes at the time of diagnosis of colorectal cancer is important in the management of the disease.

AB - The identification of mutations in germ-line DNA mismatch-repair genes at the time of diagnosis of colorectal cancer is important in the management of the disease.

KW - Adaptor Proteins, Signal Transducing

KW - Adult

KW - Analysis of Variance

KW - Base Pair Mismatch

KW - Carrier Proteins

KW - Colorectal Neoplasms, Hereditary Nonpolyposis

KW - DNA Mutational Analysis

KW - DNA Repair

KW - DNA-Binding Proteins

KW - Female

KW - Genotype

KW - Germ-Line Mutation

KW - Heterozygote

KW - Humans

KW - Immunohistochemistry

KW - Logistic Models

KW - Male

KW - Microsatellite Repeats

KW - Middle Aged

KW - MutS Homolog 2 Protein

KW - Nuclear Proteins

KW - Prognosis

KW - Prospective Studies

KW - Survival Analysis

U2 - 10.1056/NEJMoa053493

DO - 10.1056/NEJMoa053493

M3 - Article

C2 - 16807412

SN - 0028-4793

VL - 354

SP - 2751

EP - 2763

JO - New England Journal of Medicine

JF - New England Journal of Medicine

IS - 26

ER -

Identification and survival of carriers of mutations in DNA mismatch-repair genes in colon cancer

Abstract / Description of output

Keywords / Materials (for Non-textual outputs)

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