Identification of a novel multifunctional structural domain in the herpes simplex virus type 1 genome: implications for virus latency

J P Quinn, R A McGregor, C E Fiskerstrand, C Davey, J Allan, R G Dalziel

Research output: Contribution to journalArticlepeer-review

Abstract

A domain, previously termed RE1, exists within the herpes simplex virus type 1 genome potentially influencing expression of immediate early genes and the latency associated transcripts. This domain consists of 10 tandem copies of a CT-rich sequence. We demonstrate that this domain binds multiple host-cell factors that may allow RE1 to act either as a transcriptional regulator and/or to affect nucleosomal and DNA structure in the latent genome.

Original languageEnglish
Pages (from-to)2529-2532
Number of pages4
JournalJournal of General Virology
Volume79
Publication statusPublished - Oct 1998

Keywords

  • Animals
  • DNA/metabolism
  • Genome, Viral
  • HeLa Cells
  • Herpesvirus 1, Human/genetics
  • Humans
  • Rats
  • Rats, Wistar
  • Virus Latency

Fingerprint

Dive into the research topics of 'Identification of a novel multifunctional structural domain in the herpes simplex virus type 1 genome: implications for virus latency'. Together they form a unique fingerprint.

Cite this