Identification of African swine fever virus-like elements in the soft tick genome provides insights into the virus’ evolution

Jan Hendrick Forth, Leonie Forth, Samantha Lycett, Lesley Bell-Sakyi, Günther Keil, Sandra Blome, Sébastien Calvignac-Spencer, Antje Wissgott, Johannes Krause, Dirk Hoper, Helge Kampen, Martin Beer

Research output: Contribution to journalArticlepeer-review

Abstract

Background African swine fever virus (ASFV) is the only known DNA-arbovirus and a most devastating suid pathogen that, originating from a sylvatic cycle in Africa, has spread to eastern Europe and recently reached western Europe and Asia, leading to a socio-economic crisis of global proportion. However, since neither closely related viruses nor integrated viral elements have yet been identified, ASFV evolution remains a mystery.

Results Here, we show that soft ticks of the Ornithodoros moubata group, the natural arthropod vector of ASFV, harbour African swine fever virus-like integrated (ASFLI)-elements corresponding to up to 10% (over 20 kb) of the ASFV genome. Through orthologous dating and molecular clock analyses, we provide data suggesting that integration occurred over 1.47 million years ago. Furthermore, our data indicate that these elements, showing high sequence identities to modern ASFV, are maintained in the tick genome to protect the tick from infection with specific ASFV-strains through RNA interference.

Conclusion We suggest that this mechanism of protection, shaped through many years of co-evolution, is part of an evolutionary virus-vector “arms race”, a finding that has not only high impact on our understanding of the co-evolution of viruses with their hosts but also provides a glimpse into the evolution of ASFV.
Original languageEnglish
Article numberBMCB-D-20-00838
JournalBMC Biology
Early online date8 Oct 2020
DOIs
Publication statusE-pub ahead of print - 8 Oct 2020

Keywords

  • Virus
  • African Swine Fever Virus
  • phylogenetic analysis
  • Tick

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