Identification of biphenylcarboxylic acid derivatives as a novel class of bone resorption inhibitors

Rob J Van 't Hof; Aymen I Idris; Susan A Ridge; James Dunford; Iain R Greig; Stuart H Ralston

doi:10.1359/jbmr.2004.19.10.165

Identification of biphenylcarboxylic acid derivatives as a novel class of bone resorption inhibitors

Rob J Van 't Hof, Aymen I Idris, Susan A Ridge, James Dunford, Iain R Greig, Stuart H Ralston

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

A novel class of biphenylcarboxylic acid derivatives are described that inhibit osteoclastic bone resorption in vitro by promoting osteoclast apoptosis and that prevent ovariectomy-induced bone loss in vivo. The compounds act by a novel mechanism that seems to be distinct from existing antiresorptive drugs.

Original language	English
Pages (from-to)	1651-60
Number of pages	10
Journal	Journal of Bone and Mineral Research
Volume	19
Issue number	10
DOIs	https://doi.org/10.1359/jbmr.2004.19.10.165
Publication status	Published - 2004

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10.1359/jbmr.2004.19.10.165

http://onlinelibrary.wiley.com/doi/10.1359/jbmr.2004.19.10.1651/abstract

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title = "Identification of biphenylcarboxylic acid derivatives as a novel class of bone resorption inhibitors",

abstract = "A novel class of biphenylcarboxylic acid derivatives are described that inhibit osteoclastic bone resorption in vitro by promoting osteoclast apoptosis and that prevent ovariectomy-induced bone loss in vivo. The compounds act by a novel mechanism that seems to be distinct from existing antiresorptive drugs.",

author = "{Van 't Hof}, {Rob J} and Idris, {Aymen I} and Ridge, {Susan A} and James Dunford and Greig, {Iain R} and Ralston, {Stuart H}",

year = "2004",

doi = "10.1359/jbmr.2004.19.10.165",

language = "English",

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journal = "Journal of Bone and Mineral Research",

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publisher = "Wiley-Blackwell",

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T1 - Identification of biphenylcarboxylic acid derivatives as a novel class of bone resorption inhibitors

AU - Van 't Hof, Rob J

AU - Idris, Aymen I

AU - Ridge, Susan A

AU - Dunford, James

AU - Greig, Iain R

AU - Ralston, Stuart H

PY - 2004

Y1 - 2004

N2 - A novel class of biphenylcarboxylic acid derivatives are described that inhibit osteoclastic bone resorption in vitro by promoting osteoclast apoptosis and that prevent ovariectomy-induced bone loss in vivo. The compounds act by a novel mechanism that seems to be distinct from existing antiresorptive drugs.

AB - A novel class of biphenylcarboxylic acid derivatives are described that inhibit osteoclastic bone resorption in vitro by promoting osteoclast apoptosis and that prevent ovariectomy-induced bone loss in vivo. The compounds act by a novel mechanism that seems to be distinct from existing antiresorptive drugs.

U2 - 10.1359/jbmr.2004.19.10.165

DO - 10.1359/jbmr.2004.19.10.165

M3 - Article

C2 - 15355560

SN - 0884-0431

VL - 19

SP - 1651

EP - 1660

JO - Journal of Bone and Mineral Research

JF - Journal of Bone and Mineral Research

IS - 10

ER -

Identification of biphenylcarboxylic acid derivatives as a novel class of bone resorption inhibitors

Abstract / Description of output

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