Identification of cardiac malformations in mice lacking Ptdsr using a novel high-throughput magnetic resonance imaging technique

Jürgen E Schneider; Jens Böse; Simon D Bamforth; Achim D Gruber; Carol Broadbent; Kieran Clarke; Stefan Neubauer; Andreas Lengeling; Shoumo Bhattacharya

doi:10.1186/1471-213X-4-16

Identification of cardiac malformations in mice lacking Ptdsr using a novel high-throughput magnetic resonance imaging technique

Jürgen E Schneider, Jens Böse, Simon D Bamforth, Achim D Gruber, Carol Broadbent, Kieran Clarke, Stefan Neubauer, Andreas Lengeling, Shoumo Bhattacharya

Royal (Dick) School of Veterinary Studies

Research output: Contribution to journal › Article › peer-review

Abstract

Congenital heart defects are the leading non-infectious cause of death in children. Genetic studies in the mouse have been crucial to uncover new genes and signaling pathways associated with heart development and congenital heart disease. The identification of murine models of congenital cardiac malformations in high-throughput mutagenesis screens and in gene-targeted models is hindered by the opacity of the mouse embryo.

Original language	English
Pages (from-to)	16
Journal	BMC Developmental Biology
Volume	4
DOIs	https://doi.org/10.1186/1471-213X-4-16
Publication status	Published - 2004

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10.1186/1471-213X-4-16

Identification of cardiac malformations in mice lacking Ptdsr using a novel high-throughput magnetic resonance imaging technique
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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http://www.biomedcentral.com/1471-213X/4/16

Cite this

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title = "Identification of cardiac malformations in mice lacking Ptdsr using a novel high-throughput magnetic resonance imaging technique",

abstract = "Congenital heart defects are the leading non-infectious cause of death in children. Genetic studies in the mouse have been crucial to uncover new genes and signaling pathways associated with heart development and congenital heart disease. The identification of murine models of congenital cardiac malformations in high-throughput mutagenesis screens and in gene-targeted models is hindered by the opacity of the mouse embryo.",

author = "Schneider, {J{\"u}rgen E} and Jens B{\"o}se and Bamforth, {Simon D} and Gruber, {Achim D} and Carol Broadbent and Kieran Clarke and Stefan Neubauer and Andreas Lengeling and Shoumo Bhattacharya",

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AU - Schneider, Jürgen E

AU - Böse, Jens

AU - Bamforth, Simon D

AU - Gruber, Achim D

AU - Broadbent, Carol

AU - Clarke, Kieran

AU - Neubauer, Stefan

AU - Lengeling, Andreas

AU - Bhattacharya, Shoumo

PY - 2004

Y1 - 2004

N2 - Congenital heart defects are the leading non-infectious cause of death in children. Genetic studies in the mouse have been crucial to uncover new genes and signaling pathways associated with heart development and congenital heart disease. The identification of murine models of congenital cardiac malformations in high-throughput mutagenesis screens and in gene-targeted models is hindered by the opacity of the mouse embryo.

AB - Congenital heart defects are the leading non-infectious cause of death in children. Genetic studies in the mouse have been crucial to uncover new genes and signaling pathways associated with heart development and congenital heart disease. The identification of murine models of congenital cardiac malformations in high-throughput mutagenesis screens and in gene-targeted models is hindered by the opacity of the mouse embryo.

U2 - 10.1186/1471-213X-4-16

DO - 10.1186/1471-213X-4-16

M3 - Article

C2 - 15615595

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SP - 16

JO - BMC Developmental Biology

JF - BMC Developmental Biology

SN - 1471-213X

ER -

Identification of cardiac malformations in mice lacking Ptdsr using a novel high-throughput magnetic resonance imaging technique

Abstract

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