Identification of Genetic Risk Factors for Monogenic and Complex Canine Diseases

Tosso Leeb, Danika Bannasch, Jeffrey J Schoenebeck

Research output: Contribution to journalReview articlepeer-review

Abstract / Description of output

Advances in DNA sequencing and other technologies have greatly facilitated the identification of genetic risk factors for inherited diseases in dogs. We review recent technological developments based on selected examples from canine disease genetics. The identification of disease-causing variants in dogs with monogenic diseases may become a widely employed diagnostic approach in clinical veterinary medicine in the not-too-distant future. Diseases with complex modes of inheritance continue to pose challenges to researchers but have also become much more tangible than in the past. In addition to strategies for identifying genetic risk factors, we provide some thoughts on the interpretation of sequence variants that are largely inspired by developments in human clinical genetics. Expected final online publication date for the Annual Review of Animal Biosciences, Volume 11 is February 2023. Please see for revised estimates.

Original languageEnglish
JournalAnnual Review of Animal Biosciences
Early online date2 Nov 2022
Publication statusE-pub ahead of print - 2 Nov 2022


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