Identification of human-infective trypanosomes in animal reservoir of sleeping sickness in Uganda by means of serum-resistance-associated (SRA) gene

S C Welburn, K Picozzi, E M Fèvre, P G Coleman, M Odiit, M Carrington, I Maudlin

Research output: Contribution to journalArticlepeer-review

Abstract

The expansion of sleeping sickness caused by Trypanosoma brucei rhodesiense beyond its traditional focus in southeast Uganda has been linked with large-scale livestock restocking. To assess the risk presented to the human population by domestic livestock, human-infective T b rhodesiense must be distinguished from non-human-infective T brucei brucei, since both parasites can be present in cattle. We investigated the use of a simple genetic marker to characterise parasites collected from cattle in villages within the new sleeping sickness focus in Soroti District, Uganda.
Original languageEnglish
Pages (from-to)2017-9
Number of pages3
JournalThe Lancet
Volume358
Issue number9298
DOIs
Publication statusPublished - 15 Dec 2001

Keywords

  • Animals
  • Cattle
  • Disease Reservoirs
  • Gene Amplification
  • Humans
  • Membrane Glycoproteins
  • Polymorphism, Restriction Fragment Length
  • Protozoan Proteins
  • Trypanosoma brucei rhodesiense
  • Trypanosomiasis, African
  • Uganda

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