Identification of influential probe types in epigenetic predictions of human traits: implications for microarray design

Robert Hillary; Daniel L McCartney; Allan F. Mcrae; Archie Campbell; Rosie Walker; Caroline Hayward; Steve Horvath; David John Porteous; Kathryn Louise Evans; Riccardo E Marioni

doi:10.1186/s13148-022-01320-9

Identification of influential probe types in epigenetic predictions of human traits: implications for microarray design

Robert Hillary^*, Daniel L McCartney, Allan F. Mcrae, Archie Campbell, Rosie Walker, Caroline Hayward, Steve Horvath, David John Porteous, Kathryn Louise Evans, Riccardo E Marioni

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Original language	English
Journal	Clinical Epigenetics
DOIs	https://doi.org/10.1186/s13148-022-01320-9
Publication status	Published - 10 Aug 2022

Access to Document

10.1186/s13148-022-01320-9Licence: Creative Commons: Attribution (CC-BY)

OA_s13148-022-01320-9
This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.
Final published version, 2.5 MBLicence: Creative Commons: Attribution (CC-BY)

Cite this

@article{800b4fbc88884783ab0d6089ac869b5f,

title = "Identification of influential probe types in epigenetic predictions of human traits: implications for microarray design",

author = "Robert Hillary and McCartney, {Daniel L} and Mcrae, {Allan F.} and Archie Campbell and Rosie Walker and Caroline Hayward and Steve Horvath and Porteous, {David John} and Evans, {Kathryn Louise} and Marioni, {Riccardo E}",

note = "Funding Information: We are grateful to the families who took part in this study, the general practitioners and the Scottish School of Primary Care for their help in recruiting them and the wider Generation Scotland team. We are also grateful to the peer reviewers and editorial board for their suggestions and contributions towards improving the final manuscript. Funding Information: This research was funded in whole, or in part, by Wellcome [104036/Z/14/Z]. For the purpose of open access, the author has applied a CC BY public copyright licence to any Author Accepted Manuscript version arising from this submission. Generation Scotland received core support from the Chief Scientist Office of the Scottish Government Health Directorates [CZD/16/6] and the Scottish Funding Council [HR03006]. DNA methylation profiling of the Generation Scotland samples was carried out by the Genetics Core Laboratory at the University of Edinburgh Clinical Research Facility, Edinburgh, Scotland. The DNAm profiling and analysis was supported by a Wellcome Investigator Award [220857/Z/20/Z] and Grant [104036/Z/14/Z] (PI: Prof AM McIntosh) and through funding from the Brain & Behavior Research Foundation ([27404], awardee: Dr DM Howard) and the Royal College of Physicians of Edinburgh (Sim Fellowship; Awardee: Dr HC Whalley). D.J.P is supported by Wellcome as PI, and MRC and NIHR grants as co-PI, made to the University of Edinburgh. C.H. is supported by an MRC University Unit Programme Grant MC_UU_00007/10 (QTL in Health and Disease). K.L.E was supported by a grant from Alzheimer{\textquoteright}s Research UK, paid to the University of Edinburgh. R.E.M. is supported by Alzheimer{\textquoteright}s Society major project grant AS-PG-19b-010. R.F.H., S.H., and R.E.M. are supported by a National Institutes of Health U01 grant, U01AG060908–01. Publisher Copyright: {\textcopyright} 2022, The Author(s).",

year = "2022",

month = aug,

day = "10",

doi = "10.1186/s13148-022-01320-9",

language = "English",

journal = "Clinical Epigenetics",

issn = "1868-7075",

publisher = "Springer",

}

TY - JOUR

T1 - Identification of influential probe types in epigenetic predictions of human traits: implications for microarray design

AU - Hillary, Robert

AU - McCartney, Daniel L

AU - Mcrae, Allan F.

AU - Campbell, Archie

AU - Walker, Rosie

AU - Hayward, Caroline

AU - Horvath, Steve

AU - Porteous, David John

AU - Evans, Kathryn Louise

AU - Marioni, Riccardo E

N1 - Funding Information: We are grateful to the families who took part in this study, the general practitioners and the Scottish School of Primary Care for their help in recruiting them and the wider Generation Scotland team. We are also grateful to the peer reviewers and editorial board for their suggestions and contributions towards improving the final manuscript. Funding Information: This research was funded in whole, or in part, by Wellcome [104036/Z/14/Z]. For the purpose of open access, the author has applied a CC BY public copyright licence to any Author Accepted Manuscript version arising from this submission. Generation Scotland received core support from the Chief Scientist Office of the Scottish Government Health Directorates [CZD/16/6] and the Scottish Funding Council [HR03006]. DNA methylation profiling of the Generation Scotland samples was carried out by the Genetics Core Laboratory at the University of Edinburgh Clinical Research Facility, Edinburgh, Scotland. The DNAm profiling and analysis was supported by a Wellcome Investigator Award [220857/Z/20/Z] and Grant [104036/Z/14/Z] (PI: Prof AM McIntosh) and through funding from the Brain & Behavior Research Foundation ([27404], awardee: Dr DM Howard) and the Royal College of Physicians of Edinburgh (Sim Fellowship; Awardee: Dr HC Whalley). D.J.P is supported by Wellcome as PI, and MRC and NIHR grants as co-PI, made to the University of Edinburgh. C.H. is supported by an MRC University Unit Programme Grant MC_UU_00007/10 (QTL in Health and Disease). K.L.E was supported by a grant from Alzheimer’s Research UK, paid to the University of Edinburgh. R.E.M. is supported by Alzheimer’s Society major project grant AS-PG-19b-010. R.F.H., S.H., and R.E.M. are supported by a National Institutes of Health U01 grant, U01AG060908–01. Publisher Copyright: © 2022, The Author(s).

PY - 2022/8/10

Y1 - 2022/8/10

U2 - 10.1186/s13148-022-01320-9

DO - 10.1186/s13148-022-01320-9

M3 - Article

SN - 1868-7075

JO - Clinical Epigenetics

JF - Clinical Epigenetics

ER -