Identification of myopia-associated WNT7B polymorphisms provides insights into the mechanism underlying the development of myopia

Nagahama Study Group; Masahiro Miyake; Kenji Yamashiro; Yasuharu Tabara; Kenji Suda; Satoshi Morooka; Hideo Nakanishi; Chiea-Chuen Khor; Peng Chen; Fan Qiao; Isao Nakata; Yumiko Akagi-Kurashige; Norimoto Gotoh; Akitaka Tsujikawa; Akira Meguro; Sentaro Kusuhara; Ozen Polasek; Caroline Hayward; Alan F Wright; Harry Campbell; Andrea J Richardson; Maria Schache; Masaki Takeuchi; David A Mackey; Alex W Hewitt; Gabriel Cuellar; Yi Shi; Luling Huang; Zhenglin Yang; Kim Hung Leung; Patrick Y P Kao; Maurice K H Yap; Shea Ping Yip; Muka Moriyama; Kyoko Ohno-Matsui; Nobuhisa Mizuki; Stuart MacGregor; Veronique Vitart; Tin Aung; Seang-Mei Saw; E-Shyong Tai; Tien Yin Wong; Ching-Yu Cheng; Paul N Baird; Ryo Yamada; Fumihiko Matsuda; Nagahisa Yoshimura

doi:10.1038/ncomms7689

Identification of myopia-associated WNT7B polymorphisms provides insights into the mechanism underlying the development of myopia

Nagahama Study Group
, Masahiro Miyake
, Kenji Yamashiro
, Yasuharu Tabara
, Kenji Suda
, Satoshi Morooka
, Hideo Nakanishi
, Chiea-Chuen Khor
, Peng Chen
, Fan Qiao
, Isao Nakata
, Yumiko Akagi-Kurashige
, Norimoto Gotoh
, Akitaka Tsujikawa
, Akira Meguro
, Sentaro Kusuhara
, Ozen Polasek
, Caroline Hayward
, Alan F Wright
, Harry Campbell

Andrea J Richardson, Maria Schache, Masaki Takeuchi, David A Mackey, Alex W Hewitt, Gabriel Cuellar, Yi Shi, Luling Huang, Zhenglin Yang, Kim Hung Leung, Patrick Y P Kao, Maurice K H Yap, Shea Ping Yip, Muka Moriyama, Kyoko Ohno-Matsui, Nobuhisa Mizuki, Stuart MacGregor, Veronique Vitart, Tin Aung, Seang-Mei Saw, E-Shyong Tai, Tien Yin Wong, Ching-Yu Cheng, Paul N Baird, Ryo Yamada, Fumihiko Matsuda, Nagahisa Yoshimura

Research output: Contribution to journal › Article › peer-review

Abstract

Myopia can cause severe visual impairment. Here, we report a two-stage genome-wide association study for three myopia-related traits in 9,804 Japanese individuals, which was extended with trans-ethnic replication in 2,674 Chinese and 2,690 Caucasian individuals. We identify WNT7B as a novel susceptibility gene for axial length (rs10453441, Pmeta=3.9 × 10(-13)) and corneal curvature (Pmeta=2.9 × 10(-40)) and confirm the previously reported association between GJD2 and myopia. WNT7B significantly associates with extreme myopia in a case-control study with 1,478 Asian patients and 4,689 controls (odds ratio (OR)meta=1.13, Pmeta=0.011). We also find in a mouse model of myopia downregulation of WNT7B expression in the cornea and upregulation in the retina, suggesting its possible role in the development of myopia.

Original language	English
Article number	6689
Journal	Nature Communications
Volume	6
DOIs	https://doi.org/10.1038/ncomms7689
Publication status	Published - 31 Mar 2015

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Nagahama Study Group, Miyake, M., Yamashiro, K., Tabara, Y., Suda, K., Morooka, S., Nakanishi, H., Khor, C.-C., Chen, P., Qiao, F., Nakata, I., Akagi-Kurashige, Y., Gotoh, N., Tsujikawa, A., Meguro, A., Kusuhara, S., Polasek, O., Hayward, C., Wright, A. F., ... Yoshimura, N. (2015). Identification of myopia-associated WNT7B polymorphisms provides insights into the mechanism underlying the development of myopia. Nature Communications, 6, Article 6689. https://doi.org/10.1038/ncomms7689

@article{a554bbc5683a421eb283132e87caa8d3,

title = "Identification of myopia-associated WNT7B polymorphisms provides insights into the mechanism underlying the development of myopia",

abstract = "Myopia can cause severe visual impairment. Here, we report a two-stage genome-wide association study for three myopia-related traits in 9,804 Japanese individuals, which was extended with trans-ethnic replication in 2,674 Chinese and 2,690 Caucasian individuals. We identify WNT7B as a novel susceptibility gene for axial length (rs10453441, Pmeta=3.9 × 10(-13)) and corneal curvature (Pmeta=2.9 × 10(-40)) and confirm the previously reported association between GJD2 and myopia. WNT7B significantly associates with extreme myopia in a case-control study with 1,478 Asian patients and 4,689 controls (odds ratio (OR)meta=1.13, Pmeta=0.011). We also find in a mouse model of myopia downregulation of WNT7B expression in the cornea and upregulation in the retina, suggesting its possible role in the development of myopia.",

author = "\{Nagahama Study Group\} and Masahiro Miyake and Kenji Yamashiro and Yasuharu Tabara and Kenji Suda and Satoshi Morooka and Hideo Nakanishi and Chiea-Chuen Khor and Peng Chen and Fan Qiao and Isao Nakata and Yumiko Akagi-Kurashige and Norimoto Gotoh and Akitaka Tsujikawa and Akira Meguro and Sentaro Kusuhara and Ozen Polasek and Caroline Hayward and Wright, \{Alan F\} and Harry Campbell and Richardson, \{Andrea J\} and Maria Schache and Masaki Takeuchi and Mackey, \{David A\} and Hewitt, \{Alex W\} and Gabriel Cuellar and Yi Shi and Luling Huang and Zhenglin Yang and Leung, \{Kim Hung\} and Kao, \{Patrick Y P\} and Yap, \{Maurice K H\} and Yip, \{Shea Ping\} and Muka Moriyama and Kyoko Ohno-Matsui and Nobuhisa Mizuki and Stuart MacGregor and Veronique Vitart and Tin Aung and Seang-Mei Saw and E-Shyong Tai and Wong, \{Tien Yin\} and Ching-Yu Cheng and Baird, \{Paul N\} and Ryo Yamada and Fumihiko Matsuda and Nagahisa Yoshimura",

year = "2015",

month = mar,

day = "31",

doi = "10.1038/ncomms7689",

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journal = "Nature Communications",

issn = "2041-1723",

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Nagahama Study Group, Miyake, M, Yamashiro, K, Tabara, Y, Suda, K, Morooka, S, Nakanishi, H, Khor, C-C, Chen, P, Qiao, F, Nakata, I, Akagi-Kurashige, Y, Gotoh, N, Tsujikawa, A, Meguro, A, Kusuhara, S, Polasek, O, Hayward, C, Wright, AF, Campbell, H, Richardson, AJ, Schache, M, Takeuchi, M, Mackey, DA, Hewitt, AW, Cuellar, G, Shi, Y, Huang, L, Yang, Z, Leung, KH, Kao, PYP, Yap, MKH, Yip, SP, Moriyama, M, Ohno-Matsui, K, Mizuki, N, MacGregor, S, Vitart, V, Aung, T, Saw, S-M, Tai, E-S, Wong, TY, Cheng, C-Y, Baird, PN, Yamada, R, Matsuda, F & Yoshimura, N 2015, 'Identification of myopia-associated WNT7B polymorphisms provides insights into the mechanism underlying the development of myopia', Nature Communications, vol. 6, 6689. https://doi.org/10.1038/ncomms7689

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T1 - Identification of myopia-associated WNT7B polymorphisms provides insights into the mechanism underlying the development of myopia

AU - Nagahama Study Group

AU - Miyake, Masahiro

AU - Yamashiro, Kenji

AU - Tabara, Yasuharu

AU - Suda, Kenji

AU - Morooka, Satoshi

AU - Nakanishi, Hideo

AU - Khor, Chiea-Chuen

AU - Chen, Peng

AU - Qiao, Fan

AU - Nakata, Isao

AU - Akagi-Kurashige, Yumiko

AU - Gotoh, Norimoto

AU - Tsujikawa, Akitaka

AU - Meguro, Akira

AU - Kusuhara, Sentaro

AU - Polasek, Ozen

AU - Hayward, Caroline

AU - Wright, Alan F

AU - Campbell, Harry

AU - Richardson, Andrea J

AU - Schache, Maria

AU - Takeuchi, Masaki

AU - Mackey, David A

AU - Hewitt, Alex W

AU - Cuellar, Gabriel

AU - Shi, Yi

AU - Huang, Luling

AU - Yang, Zhenglin

AU - Leung, Kim Hung

AU - Kao, Patrick Y P

AU - Yap, Maurice K H

AU - Yip, Shea Ping

AU - Moriyama, Muka

AU - Ohno-Matsui, Kyoko

AU - Mizuki, Nobuhisa

AU - MacGregor, Stuart

AU - Vitart, Veronique

AU - Aung, Tin

AU - Saw, Seang-Mei

AU - Tai, E-Shyong

AU - Wong, Tien Yin

AU - Cheng, Ching-Yu

AU - Baird, Paul N

AU - Yamada, Ryo

AU - Matsuda, Fumihiko

AU - Yoshimura, Nagahisa

PY - 2015/3/31

Y1 - 2015/3/31

N2 - Myopia can cause severe visual impairment. Here, we report a two-stage genome-wide association study for three myopia-related traits in 9,804 Japanese individuals, which was extended with trans-ethnic replication in 2,674 Chinese and 2,690 Caucasian individuals. We identify WNT7B as a novel susceptibility gene for axial length (rs10453441, Pmeta=3.9 × 10(-13)) and corneal curvature (Pmeta=2.9 × 10(-40)) and confirm the previously reported association between GJD2 and myopia. WNT7B significantly associates with extreme myopia in a case-control study with 1,478 Asian patients and 4,689 controls (odds ratio (OR)meta=1.13, Pmeta=0.011). We also find in a mouse model of myopia downregulation of WNT7B expression in the cornea and upregulation in the retina, suggesting its possible role in the development of myopia.

AB - Myopia can cause severe visual impairment. Here, we report a two-stage genome-wide association study for three myopia-related traits in 9,804 Japanese individuals, which was extended with trans-ethnic replication in 2,674 Chinese and 2,690 Caucasian individuals. We identify WNT7B as a novel susceptibility gene for axial length (rs10453441, Pmeta=3.9 × 10(-13)) and corneal curvature (Pmeta=2.9 × 10(-40)) and confirm the previously reported association between GJD2 and myopia. WNT7B significantly associates with extreme myopia in a case-control study with 1,478 Asian patients and 4,689 controls (odds ratio (OR)meta=1.13, Pmeta=0.011). We also find in a mouse model of myopia downregulation of WNT7B expression in the cornea and upregulation in the retina, suggesting its possible role in the development of myopia.

U2 - 10.1038/ncomms7689

DO - 10.1038/ncomms7689

M3 - Article

C2 - 25823570

SN - 2041-1723

VL - 6

JO - Nature Communications

JF - Nature Communications

M1 - 6689

ER -

Identification of myopia-associated WNT7B polymorphisms provides insights into the mechanism underlying the development of myopia

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