Identification of novel genes and pathways affecting Salmonella type III secretion system 1 using a contact-dependent hemolysis assay

Terry R. Field, Abigail N. Layton, Jennie Bispham, Mark P. Stevens, Edouard E. Galyov

Research output: Contribution to journalArticlepeer-review

Abstract

We screened 5,700 Salmonella enterica serovar Typhimurium mutants for defects in type III secretion system 1 (T3SS-1)-mediated contact-dependent hemolysis to identify novel genes and pathways affecting the activity of T3SS-1. Our data suggest that previously unrecognized factors such as type I fimbriae may modulate the expression, activity, or deployment of this key virulence factor.

Original languageEnglish
Pages (from-to)3393-3398
Number of pages6
JournalJournal of Bacteriology
Volume190
Issue number9
DOIs
Publication statusPublished - May 2008

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