Identification of novel genes and pathways affecting Salmonella type III secretion system 1 using a contact-dependent hemolysis assay

Terry R. Field; Abigail N. Layton; Jennie Bispham; Mark P. Stevens; Edouard E. Galyov

doi:10.1128/JB.01189-07

Identification of novel genes and pathways affecting Salmonella type III secretion system 1 using a contact-dependent hemolysis assay

Terry R. Field, Abigail N. Layton, Jennie Bispham, Mark P. Stevens, Edouard E. Galyov

Royal (Dick) School of Veterinary Studies

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

We screened 5,700 Salmonella enterica serovar Typhimurium mutants for defects in type III secretion system 1 (T3SS-1)-mediated contact-dependent hemolysis to identify novel genes and pathways affecting the activity of T3SS-1. Our data suggest that previously unrecognized factors such as type I fimbriae may modulate the expression, activity, or deployment of this key virulence factor.

Original language	English
Pages (from-to)	3393-3398
Number of pages	6
Journal	Journal of Bacteriology
Volume	190
Issue number	9
DOIs	https://doi.org/10.1128/JB.01189-07
Publication status	Published - May 2008

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Identification of novel genes and pathways affecting Salmonella type III secretion system 1 using a contact-dependent hemolysis assayFinal published version, 227 KB

http://jb.asm.org/content/190/9/3393

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title = "Identification of novel genes and pathways affecting Salmonella type III secretion system 1 using a contact-dependent hemolysis assay",

abstract = "We screened 5,700 Salmonella enterica serovar Typhimurium mutants for defects in type III secretion system 1 (T3SS-1)-mediated contact-dependent hemolysis to identify novel genes and pathways affecting the activity of T3SS-1. Our data suggest that previously unrecognized factors such as type I fimbriae may modulate the expression, activity, or deployment of this key virulence factor.",

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AU - Stevens, Mark P.

AU - Galyov, Edouard E.

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AB - We screened 5,700 Salmonella enterica serovar Typhimurium mutants for defects in type III secretion system 1 (T3SS-1)-mediated contact-dependent hemolysis to identify novel genes and pathways affecting the activity of T3SS-1. Our data suggest that previously unrecognized factors such as type I fimbriae may modulate the expression, activity, or deployment of this key virulence factor.

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DO - 10.1128/JB.01189-07

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JF - Journal of Bacteriology

IS - 9

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Identification of novel genes and pathways affecting Salmonella type III secretion system 1 using a contact-dependent hemolysis assay

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