Projects per year
METHODS: 5032 plasma proteins were measured in 1061 cognitively normal individuals (628 females and 433 males), nearly 90% of whom had magnetic resonance imaging measures of hippocampal volume (as N) and white matter hyperintensities (as V).
RESULTS: Differential protein expression analysis and co-expression network analysis revealed different proteins and modules associated with N and V respectively. Furthermore, causal mediation analysis revealed four proteins mediated sex-related difference in neurodegeneration and one protein mediated such difference in vascular damage.
DISCUSSION: Once validated, the identified proteins could help to select cognitively normal individuals with N and V pathology for Alzheimer’s disease clinical trials and provide targets for further mechanistic studies on brain sex-differences, leading to sex-specific therapeutic strategies.
|Journal||Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring|
|Early online date||27 Sep 2021|
|Publication status||Published - 2021|
- plasma proteomics
- vascular damage
- sex-related difference
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- 1 Finished
1/10/17 → 30/06/19