Identification of two distinct subsets of bovine gamma delta T cells with unique cell surface phenotype and tissue distribution

Niall MacHugh, JK Mburu, M J Carol, C R Wyatt, J A Orden, W.C. Davis

Research output: Contribution to journalArticlepeer-review

Abstract

We describe the characterization of two subsets of bovine gamma delta T cells having distinct cell surface phenotype and tissue distribution. One population expresses the previously described 215,000 MW WC1 antigen and is negative for the cell-surface differentiation antigens CD2, CD4, and CD8. The second population expresses CD2 and CD8 but not WC1 and appears to have a T-cell receptor (TCR) rearrangement distinct from that of the WC1+ population. The WC1- population is found in large numbers in spleen and intestine. In addition, this subset is not recognized by a number of monoclonal antibodies (mAbs) specific for TCR families that are well represented in the WC1+ population. The results indicate that the gamma delta T-cell population in cattle is considerably larger than previously described and that this population can be subdivided into two distinct subsets based on cell-surface phenotype and tissue distribution.
Original languageEnglish
Pages (from-to)340-5
Number of pages6
JournalImmunology
Volume92
Issue number3
Publication statusPublished - Nov 1997

Keywords

  • Animals
  • Antigens, Surface/analysis
  • Cattle/immunology
  • Flow Cytometry
  • Immunoenzyme Techniques
  • Immunophenotyping
  • Lymph Nodes/immunology
  • Receptors, Antigen, T-Cell, gamma-delta
  • Spleen/immunology
  • T-Lymphocyte Subsets/immunology
  • Thymus Gland/immunology
  • Transfection

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