Identifying and searching for conserved RNA localisation signals

Russell S Hamilton, Ilan Davis

Research output: Chapter in Book/Report/Conference proceedingOther chapter contribution

Abstract

RNA localisation is an important mode of delivering proteins to their site of function. Cis-acting signals within the RNAs, which can be thought of as zip-codes, determine the site of localisation. There are few examples of fully characterised RNA signals, but the signals are thought to be defined through a combination of primary, secondary, and tertiary structures. In this chapter, we describe a selection of computational methods for predicting RNA secondary structure, identifying localisation signals, and searching for similar localisation signals on a genome-wide scale. The chapter is aimed at the biologist rather than presenting the details of each of the individual methods.
Original languageEnglish
Title of host publicationRNA Detection and Visualization
Place of PublicationTotowa, NJ
PublisherHumana Press
Pages447-466
Number of pages20
ISBN (Electronic)978-1-61779-005-8
ISBN (Print)978-1-61779-004-1
DOIs
Publication statusPublished - 2011

Publication series

NameMethods in Molecular Biology (Methods and Protocols)
PublisherHumana Press
Volume714
ISSN (Print)1064-3745
ISSN (Electronic)1940-6029

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