Projects per year
METHODS: We systematically reviewed the literature for studies comparing dementia coding in routinely-collected datasets to any expert-led reference standard. We recorded study characteristics and two accuracy measures – positive predictive value (PPV) and sensitivity.
RESULTS: We identified 27 eligible studies with 25 estimating PPV and eight estimating sensitivity. Study settings and methods varied widely. For all-cause dementia, PPVs ranged from 33-100%, but 16/27 were >75%. Sensitivities ranged from 21-86%. PPVs for Alzheimer’s disease (range 57-100%) were generally higher than for vascular dementia (range 19-91%).
DISCUSSION: Linkage to routine healthcare data can achieve a high PPV and reasonable sensitivity in certain settings. Given the heterogeneity in accuracy estimates, cohorts should ideally conduct their own setting-specific validation.
- Key words: dementia; Alzheimer disease; dementia, vascular; clinical coding; epidemiology; prospective studies; cohort studies; sensitivity; positive predictive value; predictive value of tests
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- 2 Finished
Predicting dementia outcomes using simple, non-invasive assessments: a prospective population-based study.
1/08/16 → 31/07/19
10/08/15 → 31/08/17