Identifying RNA editing sites using RNA sequencing data alone

Gokul Ramaswami, Rui Zhang, Robert Piskol, Liam P Keegan, Patricia Deng, Mary A O'Connell, Jin Billy Li

Research output: Contribution to journalArticlepeer-review

Abstract

We show that RNA editing sites can be called with high confidence using RNA sequencing data from multiple samples across either individuals or species, without the need for matched genomic DNA sequence. We identified many previously unidentified editing sites in both humans and Drosophila; our results nearly double the known number of human protein recoding events. We also found that human genes harboring conserved editing sites within Alu repeats are enriched for neuronal functions.
Original languageEnglish
Pages (from-to)128-32
Number of pages5
JournalNature Methods
Volume10
Issue number2
DOIs
Publication statusPublished - Feb 2013

Keywords

  • Adenosine
  • Alu Elements
  • Animals
  • Computational Biology
  • Drosophila melanogaster
  • Humans
  • Inosine
  • RNA Editing
  • Sequence Analysis, RNA

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