IDEOM: an Excel interface for analysis of LC--MS-based metabolomics data

Darren J Creek, Andris Jankevics, Karl EV Burgess, Rainer Breitling, Michael P Barrett

Research output: Contribution to journalArticlepeer-review

Abstract

Summary: The application of emerging metabolomics technologies to the comprehensive investigation of cellular biochemistry has been limited by bottlenecks in data processing, particularly noise filtering and metabolite identification. IDEOM provides a user-friendly data processing application that automates filtering and identification of metabolite peaks, paying particular attention to common sources of noise and false identifications generated by liquid chromatography–mass spectrometry (LC–MS) platforms. Building on advanced processing tools such as mzMatch and XCMS, it allows users to run a comprehensive pipeline for data analysis and visualization from a graphical user interface within Microsoft Excel, a familiar program for most biological scientists.

Availability and implementation: IDEOM is provided free of charge at http://mzmatch.sourceforge.net/ideom.html, as a macro-enabled spreadsheet (.xlsb). Implementation requires Microsoft Excel (2007 or later). R is also required for full functionality.

Contact:michael.barrett@glasgow.ac.uk

Supplementary Information:Supplementary data are available at Bioinformatics online.
Original languageEnglish
Pages (from-to)1048-1049
Number of pages2
JournalBioinformatics
Volume28
Issue number7
Early online date4 Feb 2012
DOIs
Publication statusPublished - 1 Apr 2012

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