IGF-I signalling in bone growth: inhibitory actions of dexamethasone and IL-1beta

Vicky E Macrae; S Faisal Ahmed; Talat Mushtaq; Colin Farquharson

doi:10.1016/j.ghir.2007.05.002

IGF-I signalling in bone growth: inhibitory actions of dexamethasone and IL-1beta

Vicky E Macrae, S Faisal Ahmed, Talat Mushtaq, Colin Farquharson

Royal (Dick) School of Veterinary Studies

Research output: Contribution to journal › Article › peer-review

Abstract

To determine if glucocorticoids and proinflammatory cytokines inhibit bone growth through a common mechanism involving impaired IGF-I signalling.

Original language	English
Pages (from-to)	435-9
Number of pages	5
Journal	Growth Hormone and IGF Research
Volume	17
Issue number	5
DOIs	https://doi.org/10.1016/j.ghir.2007.05.002
Publication status	Published - Oct 2007

Keywords

Animals
Bone Development
Cell Line
Chondrocytes
Dexamethasone
Insulin-Like Growth Factor I
Interleukin-1beta
Metatarsal Bones
Mice
Organ Culture Techniques
Signal Transduction

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10.1016/j.ghir.2007.05.002

IGF-I signalling in bone growth inhibitory actions of dexamethasone and IL-1betaAccepted author manuscript, 129 KB

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@article{1352b618cf644ac7a17cc142a66a4c8e,

title = "IGF-I signalling in bone growth: inhibitory actions of dexamethasone and IL-1beta",

abstract = "To determine if glucocorticoids and proinflammatory cytokines inhibit bone growth through a common mechanism involving impaired IGF-I signalling.",

keywords = "Animals, Bone Development, Cell Line, Chondrocytes, Dexamethasone, Insulin-Like Growth Factor I, Interleukin-1beta, Metatarsal Bones, Mice, Organ Culture Techniques, Signal Transduction",

author = "Macrae, {Vicky E} and Ahmed, {S Faisal} and Talat Mushtaq and Colin Farquharson",

year = "2007",

month = oct,

doi = "10.1016/j.ghir.2007.05.002",

language = "English",

volume = "17",

pages = "435--9",

journal = "Growth Hormone and IGF Research",

issn = "1096-6374",

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T1 - IGF-I signalling in bone growth

T2 - inhibitory actions of dexamethasone and IL-1beta

AU - Macrae, Vicky E

AU - Ahmed, S Faisal

AU - Mushtaq, Talat

AU - Farquharson, Colin

PY - 2007/10

Y1 - 2007/10

N2 - To determine if glucocorticoids and proinflammatory cytokines inhibit bone growth through a common mechanism involving impaired IGF-I signalling.

AB - To determine if glucocorticoids and proinflammatory cytokines inhibit bone growth through a common mechanism involving impaired IGF-I signalling.

KW - Animals

KW - Bone Development

KW - Cell Line

KW - Chondrocytes

KW - Dexamethasone

KW - Insulin-Like Growth Factor I

KW - Interleukin-1beta

KW - Metatarsal Bones

KW - Mice

KW - Organ Culture Techniques

KW - Signal Transduction

U2 - 10.1016/j.ghir.2007.05.002

DO - 10.1016/j.ghir.2007.05.002

M3 - Article

C2 - 17590365

VL - 17

SP - 435

EP - 439

JO - Growth Hormone and IGF Research

JF - Growth Hormone and IGF Research

SN - 1096-6374

IS - 5

ER -

IGF-I signalling in bone growth: inhibitory actions of dexamethasone and IL-1beta

Abstract

Keywords

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